McNally J N, de Ronde J
Br J Cancer Suppl. 1978 Jun;3:90-4.
Measurements of effect of pairs of the sensitizers PNAP, misonidazole and oxygen have shown that if one sensitizer is giving an enhancement ratio (ER) of about 1.6 or less and the other is giving a larger ER, the combination behaves as if only the latter is present. There is only an additive effect of the two if they both give ERs less than 1.6 or greater than 1.6. These results show that at low concentrations sensitizers only act on damage associated with the "fast component" of the oxygen effect. This could result from interaction with two distinct species, or there could be only one critical species formed initially but more than one step by which it could be converted to a lethal form.
对敏化剂卟啉钠（PNAP）、甲硝唑和氧气两两组合的效应测量表明，如果一种敏化剂的增强比（ER）约为1.6或更低，而另一种敏化剂的ER更大，那么该组合的行为就好像只存在后者一样。只有当两者的ER都小于1.6或都大于1.6时，两者才会产生相加效应。这些结果表明，在低浓度下，敏化剂仅作用于与氧效应“快速成分”相关的损伤。这可能是由于与两种不同的物质相互作用，或者最初可能只形成一种关键物质，但它可以通过不止一步转化为致死形式。
