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肛管腺癌：病例报告、文献回顾及生存比较分析。

Anal adenocarcinoma: case report, literature review and comparative survival analysis.

机构信息

Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

Medicine, VA Connecticut Healthcare System-West Haven Campus, West Haven, Connecticut, USA.

出版信息

BMJ Open Gastroenterol. 2021 Jul;8(1). doi: 10.1136/bmjgast-2021-000661.

DOI:10.1136/bmjgast-2021-000661
PMID:34244243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8273449/
Abstract

INTRODUCTION

Anal adenocarcinoma is a rare malignancy with a poor prognosis.

METHODS

We present a case of rare anal adenocarcinoma in a patient with normal screening colonoscopy. Using the Surveillance, Epidemiology and End Result database between 2000 and 2016, we performed survival analysis among individuals>20 years old comparing anal and rectal cancers.

RESULTS

Survival analysis showed that anal adenocarcinoma is associated with worse outcomes compared with rectal adenocarcinoma and anal squamous cell carcinoma.

DISCUSSION

This case and survival data illustrate the importance of prompt investigation of symptoms irrespective of colorectal cancer screening status with careful attention to examination of the anal area.

摘要

简介

肛门腺癌是一种罕见的恶性肿瘤，预后不良。

方法

我们报告了一例罕见的肛门腺癌病例，患者的结肠镜筛查结果正常。利用 2000 年至 2016 年的监测、流行病学和最终结果数据库，我们对 20 岁以上人群进行了生存分析，比较了肛门癌和直肠癌。

结果

生存分析表明，肛门腺癌与直肠癌和肛门鳞状细胞癌相比，预后更差。

讨论

本病例和生存数据表明，无论结直肠癌筛查状况如何，出现症状时都应及时进行调查，仔细注意肛门区域的检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2324/8273449/dfe3466eb3dd/bmjgast-2021-000661f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2324/8273449/dfe3466eb3dd/bmjgast-2021-000661f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2324/8273449/dfe3466eb3dd/bmjgast-2021-000661f01.jpg

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本文引用的文献

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2
Impact of Surgical Resection on Survival Outcomes After Chemoradiotherapy in Anal Adenocarcinoma.根治性手术对接受放化疗的肛门腺癌患者生存结局的影响。
J Natl Compr Canc Netw. 2019 Oct 1;17(10):1203-1210. doi: 10.6004/jnccn.2019.7309.
3
Anal adenocarcinoma: Treatment outcomes and trends in a rare disease entity.
肛门腺癌：一种罕见疾病实体的治疗结果和趋势。
Cancer Med. 2019 Jul;8(8):3855-3863. doi: 10.1002/cam4.2076. Epub 2019 Jun 7.
4
Survival Outcomes and Patterns of Management for Anal Adenocarcinoma.肛管腺癌的生存结局和治疗模式。
Ann Surg Oncol. 2019 May;26(5):1351-1357. doi: 10.1245/s10434-019-07202-4. Epub 2019 Feb 4.
5
Comparative Survival of Patients With Anal Adenocarcinoma, Squamous Cell Carcinoma of the Anus, and Rectal Adenocarcinoma.肛管腺癌、肛门鳞状细胞癌和直肠腺癌患者的生存情况比较
Clin Colorectal Cancer. 2016 Mar;15(1):47-53. doi: 10.1016/j.clcc.2015.07.007. Epub 2015 Aug 1.
6
Adenocarcinoma of the anal canal - a systematic review.肛管腺癌——系统评价。
Colorectal Dis. 2013 Dec;15(12):1481-8. doi: 10.1111/codi.12325.
7
Changing patterns of anal canal carcinoma in the United States.美国肛门管癌的发病模式变化。
J Clin Oncol. 2013 Apr 20;31(12):1569-75. doi: 10.1200/JCO.2012.45.2524. Epub 2013 Mar 18.