Cardiovascular Department, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.
Diabetes and Metabolic Department, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.
Sci Rep. 2021 Jul 9;11(1):14242. doi: 10.1038/s41598-021-93753-0.
Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and the severity of coronary artery disease (CAD). The present study evaluated whether the HNA fraction is correlated with coronary artery stenosis in 140 patients considered to have a high risk of CAD or who were suspected of having acute coronary syndrome. The severity of CAD was defined by the number of stenotic coronary vessels and a severity score system (the Gensini score). HNA measurements were performed using our newly established high-performance liquid chromatography methodology. The results had shown that HNA was significantly increased in patients with three-vessel disease, compared with those without CAD or with single-vessel disease (p = 0.025), and was positively correlated with the Gensini score (ρ = 0.421, p < 0.001). A multivariate analysis showed that the number of stenotic vessels was an independent and significant factor associated with HNA (ρ = 1.246, p = 0.012). A logistic regression analysis showed that HNA was a strong predictor of multivessel CAD (odds ratio, 1.12; 95% confidence interval, 1.020-1.229; p = 0.017). These findings indicate that the measurement of HNA could be clinically practical for predicting the severity of coronary artery stenosis.
人非巯基白蛋白（HNA），是血清白蛋白的氧化形式，已被报道为氧化应激相关疾病的有用标志物；然而，很少有报道研究 HNA 与冠状动脉疾病（CAD）严重程度之间的关系。本研究评估了在 140 名被认为有 CAD 高风险或疑似急性冠状动脉综合征的患者中，HNA 分数是否与冠状动脉狭窄相关。CAD 的严重程度通过狭窄冠状动脉数量和严重程度评分系统（Gensini 评分）来定义。使用我们新建立的高效液相色谱法对 HNA 进行了测量。结果表明，与无 CAD 或单支病变患者相比，三支病变患者的 HNA 明显升高（p=0.025），并且与 Gensini 评分呈正相关（ρ=0.421，p<0.001）。多变量分析表明，狭窄血管数量是与 HNA 相关的独立且重要的因素（ρ=1.246，p=0.012）。逻辑回归分析表明，HNA 是多支 CAD 的强预测因子（比值比，1.12；95%置信区间，1.020-1.229；p=0.017）。这些发现表明，HNA 的测量可能在临床上对预测冠状动脉狭窄的严重程度具有实际意义。
