Kobayashi Yuka, Suzuki Ryo, Yasukawa Keiko, Oba Koji, Yamauchi Toshimasa, Yatomi Yutaka, Kadowaki Takashi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Diabetes, Metabolism and Endocrinololy, Tokyo Medical University, Tokyo, Japan.
Metabol Open. 2020 Mar 14;6:100032. doi: 10.1016/j.metop.2020.100032. eCollection 2020 Jun.
Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications.
白蛋白有一种氧化形式，称为非巯基白蛋白（HNA），它反映全身氧化应激。血清HNA水平与糖尿病并发症之间的关联尚未见报道。在这项横断面研究中，我们调查了164名糖尿病患者，以评估HNA%（在总白蛋白中的比例）与各种临床参数之间的相关性。HNA%与多种并发症的严重程度显著相关，包括神经病变（分别为23.3±4.1%和26.2±5.1%）和肾病（分别为24.1±3.9%、24.6±4.2%、28.5±6.1%、31.3±5.7%、37.8±2.9%，1/2/3/4/5期）。这些发现突出了氧化应激的普遍重要性，表明HNA%有可能作为糖尿病并发症严重程度的通用标志物。
