Pediatric Intensive Care Unit, Rennes University Hospital, 35200 Rennes, France.
Pediatric Intensive Care Unit, Rennes University Hospital, 35200 Rennes, France.
Arch Pediatr. 2021 Aug;28(6):488-490. doi: 10.1016/j.arcped.2021.04.012. Epub 2021 Jul 8.
We report the case of a 7-year-old girl with septic shock and coagulopathy associated with purpura fulminans (PF) and diffuse alveolar hemorrhage (DAH) due to group A Streptococcus (GAS) infection identified with 16S ribosomal RNA analysis performed on the skin biopsy. GAS infection with PF associated with DAH is rare in healthy young children but pediatricians should be aware of this condition because of the poor prognosis. The initial treatment for circulatory failure and severe disseminated intravascular coagulation as well as the prompt initiation of antibiotic treatment may be crucial for the outcomes of S. pyogenes PF.
我们报告了一例 7 岁女孩的病例，她因 A 组链球菌（GAS）感染导致败血性休克和凝血病合并暴发性紫癜（PF）和弥漫性肺泡出血（DAH），皮肤活检的 16S 核糖体 RNA 分析对此进行了鉴定。健康的年轻儿童中 GAS 感染合并 PF 并伴有 DAH 较为罕见，但儿科医生应该对此有所了解，因为预后较差。循环衰竭和严重弥散性血管内凝血的初始治疗以及抗生素治疗的及时启动对于 GAS 感染性 PF 的结局可能至关重要。
