Consultant for the World Health Organization Regional Office for Africa, São Tomé, São Tomé and Príncipe.
Health Care Directorate, São Tomé, São Tomé and Príncipe.
Int J Infect Dis. 2021 Oct;110 Suppl 1:S69-S76. doi: 10.1016/j.ijid.2021.06.050. Epub 2021 Jul 9.
In 2016-18, the Democratic Republic of São Tomé and Príncipe suffered a necrotic skin infection epidemic.
A surveillance system was established after increased hospitalisations for this infection. Microbiology results were available for samples analysed in December 2016 and March 2017 using whole genome sequencing and metagenomics. Negative binomial regression was used to study the association of weather conditions with monthly case counts in a time-series analysis.
From October 2016 to October 2018, the epidemic cumulative attack rate was 1.5%. The first peak lasted 5 months, accounting for one-third of total cases. We could not conclusively identify the aetiological agent(s) due to the country's lack of microbiology capacity. Increased relative humidity was associated with increased monthly cases (incidence rate ratio (IRR) 1.05, 95% CI 1.02-1.09), and higher precipitation in the previous month with a higher number of cases in the following month (months with 0-49 mm rainfall compared with months with 50-149 mm and ≥150 mm: IRR 1.44, 95 % CI 1.13-1.78 and 1.50, 95% CI 1.12-1.99, respectively).
This epidemic was favoured by increased relative humidity and precipitation, potentially contributing to community-based transmission of ubiquitous bacterial strains superinfecting skin wounds.
World Health Organization Regional Office for Africa, Ministry of Health.
2016-18 年，圣多美和普林西比民主共和国发生了坏死性皮肤感染疫情。
在因这种感染而住院的人数增加后，建立了一个监测系统。2016 年 12 月和 2017 年 3 月，使用全基因组测序和宏基因组学对微生物学结果进行了分析。在时间序列分析中，使用负二项回归研究天气条件与每月病例数的关联。
从 2016 年 10 月到 2018 年 10 月，疫情累计发病率为 1.5%。第一个高峰持续了 5 个月，占总病例数的三分之一。由于该国缺乏微生物学能力，我们无法确定病因（s）。相对湿度的增加与每月病例数的增加相关（发病率比（IRR）1.05，95%CI 1.02-1.09），上月降水量较高与下月病例数较多相关（降水量为 0-49mm 的月份与 50-149mm 和≥150mm 的月份相比：IRR 1.44，95%CI 1.13-1.78 和 1.50，95%CI 1.12-1.99）。
这种疫情受到相对湿度和降水增加的促进，可能有助于社区传播普遍存在的细菌菌株，使皮肤伤口继发感染。
世界卫生组织非洲区域办事处、卫生部。
