Alzahra research center, Isfahan University of Medical Sciences, Isfahan, Iran.
Alzahra research center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mult Scler Relat Disord. 2021 Sep;54:103119. doi: 10.1016/j.msard.2021.103119. Epub 2021 Jun 30.
Multiple sclerosis (MS) is an inflammatory demyelinating CNS disease and the most common neurological immune-mediated disorder. Due to its progressive format, it affects patients' quality of life (QoL) significantly. This study aimed to evaluate epidemiologic parameters of MS in the Asia and Oceania continents.
A comprehensive literature search on October 1st, 2020, was performed in PubMed, Scopus, and Web of Science to retrieve original population-based studies on MS epidemiology in the Asian and Oceanian countries, published between January 1st, 1985 and October 1st, 2020. The designed search strategy was repeated for each country, and the relevant referenced articles were added to our database. A random-effect model was used to combine the epidemiological estimates, and subgroup analysis was also performed by continent, region, and country, when possible. Meta-regression analysis was done to evaluate the effects of Human Developmental Index (HDI), latitude, and study period on the epidemiologic parameters.
A total of 3,109 publications were found, of which 89 articles met the eligibility criteria and were included for data extraction. These articles provided data on prevalence, incidence, and mean age at disease onset in 18 countries in Asia and Oceania, including Iran, Turkey, Cyprus, Kuwait, Saudi Arabia, Qatar, UAE, Jordan, Israel, India, Malaysia, China, Hong Kong, Taiwan, Republic of Korea, Japan, Australia, and New Zealand. The pooled total prevalence, incidence, and mean age of onset in Asia and Oceania were 37.89/100000 (95% CI: 35.65 - 40.142), 2.40/100000 (95% CI: 2.22 - 2.58), and 28.21 (95% CI: 27.55 - 28.88), respectively. MS prevalence and incidence in the female gender (68.7/100000 and 4.42/100000, respectively) were infinitely higher than in the male gender (24.52/100000 and 2.06/100000, respectively). Our subgroup analysis showed that MS was much more prevalent in Australia and West Asia among the studied area. The meta-regression showed that the total incidence decreased with an increase in the HDI, and the total prevalence in Asia increased with increasing latitude gradients. Also, the study period had a positive effect on the total prevalence and incidence in Asia and Oceania.
MS prevalence and incidence have increased in recent decades. This study highlights the need for further studies to elucidate MS's geographical and temporal variations' exact etiologies.
多发性硬化症（MS）是一种中枢神经系统炎症性脱髓鞘疾病，也是最常见的神经免疫介导性疾病。由于其进行性的特点，显著影响了患者的生活质量（QoL）。本研究旨在评估亚洲和大洋洲地区 MS 的流行病学参数。
2020 年 10 月 1 日，在 PubMed、Scopus 和 Web of Science 上进行了全面的文献检索，以检索 1985 年 1 月 1 日至 2020 年 10 月 1 日期间发表的亚洲和大洋洲国家基于人群的 MS 流行病学的原始研究。为每个国家设计了重复的搜索策略，并将相关的参考文献添加到我们的数据库中。使用随机效应模型来合并流行病学估计值，并在可能的情况下，通过大陆、地区和国家进行亚组分析。进行了荟萃回归分析，以评估人类发展指数（HDI）、纬度和研究期对流行病学参数的影响。
共发现 3109 篇出版物，其中 89 篇文章符合入选标准，并纳入数据提取。这些文章提供了亚洲和大洋洲 18 个国家的患病率、发病率和发病年龄平均值的数据，包括伊朗、土耳其、塞浦路斯、科威特、沙特阿拉伯、卡塔尔、阿联酋、约旦、以色列、印度、马来西亚、中国、香港、台湾、韩国、日本、澳大利亚和新西兰。亚洲和大洋洲的总患病率、发病率和平均发病年龄分别为 37.89/100000（95%CI：35.65-40.142）、2.40/100000（95%CI：2.22-2.58）和 28.21（95%CI：27.55-28.88）。女性（68.7/100000 和 4.42/100000）的 MS 患病率和发病率均远高于男性（24.52/100000 和 2.06/100000）。我们的亚组分析表明，在研究区域中，MS 在澳大利亚和西亚更为普遍。荟萃回归显示，总发病率随人类发展指数的增加而降低，亚洲的总患病率随纬度梯度的增加而增加。此外，研究期间对亚洲和大洋洲的总患病率和发病率有积极影响。
近年来，MS 的患病率和发病率有所增加。本研究强调需要进一步研究，以阐明 MS 的地理和时间变化的确切病因。
