Wang Xiaoxiao, Suppa Mariano, Bruderer Pascal, Sirtaine Nicolas, Aspeslagh Sandrine, Kerger Joseph
Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Department of Dermatology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Case Rep Oncol. 2021 Jun 15;14(2):861-867. doi: 10.1159/000514806. eCollection 2021 May-Aug.
Immunotherapy has become the standard of care for various cancer types. The widespread use of immune checkpoints inhibitors confronts us with a whole range of novel immune-related adverse events. Skin toxicity is one of the most frequent adverse events. In this article, we report a case of anti-PD-1 induced late bullous pemphigoid (BP) with mucosal erosions and associated with a troublesome neurological disorder of undetermined origin in a patient with metastatic melanoma. Skin biopsy was essential to make the diagnosis and rapid initiation of systemic prednisolone played a role in favorable clinical outcome of BP. We will discuss the difficulty of early diagnosis of BP, its unusual association with neurological disorders, and the specific management of this particular dermatological entity.
免疫疗法已成为多种癌症类型的标准治疗方法。免疫检查点抑制剂的广泛应用使我们面临一系列全新的免疫相关不良事件。皮肤毒性是最常见的不良事件之一。在本文中，我们报告了1例抗程序性死亡蛋白1（PD-1）诱导的迟发性大疱性类天疱疮（BP），伴有黏膜糜烂，并与1例转移性黑色素瘤患者不明原因的棘手神经系统疾病相关。皮肤活检对于确诊至关重要，迅速开始全身使用泼尼松龙对BP的良好临床结局起到了作用。我们将讨论BP早期诊断的困难、其与神经系统疾病的异常关联以及这一特殊皮肤病实体的具体管理。
