一种改良测量方法，用于通过扫频源光学相干断层扫描血管造影术研究息肉样脉络膜血管病变的脉络膜毛细血管血流信号缺失情况。
A modified measuring method to investigate the choriocapillaris flow void of polypoidal choroidal vasculopathy with swept source optical coherence tomography angiography.
作者信息
Wu Huajui, Sekiryu Tetsuju, Sugano Yukinori, Itagaki Kanako, Kasai Akihito, Shintake Hiroaki
机构信息
Department of Ophthalmology, Fukushima Medical University, Fukushima City, Fukushima Pref., Japan.
出版信息
Quant Imaging Med Surg. 2021 Jul;11(7):3146-3156. doi: 10.21037/qims-20-1027.
BACKGROUND
To propose a modified method to investigate the flow void of polypoidal choroidal vasculopathy (PCV) choriocapillaris.
METHODS
This paper involves a retrospective study. Included 30 PCV affect eyes, 30 old control eyes, 20 young control eyes, 15 affect eyes with anti-VEGF intravitreal injection treatment, and 8 fellow eyes of anti-VEGF intravitreal injection treatment group. After the choriocapillaris slab [10 µm thick starting 30 µm beneath to the retinal pigment epithelium (RPE)-fit reference] was extracted from macular optical coherence tomography angiography 6×6-mm scans, the flow void was segmented by the Phansalkar method. We analyzed the flow void sizes-frequency histogram in order to investigate the differences of flow void proportion between groups. Then we verified the differences between groups after anti-VEGF intravitreal injection treatment.
RESULTS
On the difference curve between the PCV group and Old control group, there was a peak appeared at the flow void sizes range from 900 to 1,125 µm. The average number of flow void sizes from 900 to 1,125 µm was significantly higher in the Old control group than that in the Young control group (P<0.05) and there was no difference between the affect eyes group and the Old control group. The proportion of flow void sizes from 900 to 1,125 µm were remarkably higher in the affect eyes group compared to the Old control group (P<0.05), showing no difference between the Young control group and the Old control group. The average number of flow void sizes from 900 to 1,125 µm and the proportion of flow void sizes range from 900 to 1,125 µm were significantly higher in the treatment group after the treatment (P<0.05) and there was no difference in the fellow eyes of treatment group. The choroidal thickness was significantly reduced after the treatment of the treatment group (P<0.001), while the fellow eyes of the treatment group had no difference.
CONCLUSIONS
Our method was specific for the pathological changes in choriocapillaris structures of PCV affect eyes, fellow eyes, and the affect eyes after anti-VEGF treatment.
背景
提出一种改良方法用于研究息肉状脉络膜血管病变（PCV）脉络膜毛细血管的血流信号缺失情况。
方法
本研究为回顾性研究。纳入30只PCV患眼、30只老年对照眼、20只青年对照眼、15只接受抗VEGF玻璃体腔内注射治疗的患眼以及8只抗VEGF玻璃体腔内注射治疗组的对侧眼。从黄斑光学相干断层扫描血管造影6×6-mm扫描中提取脉络膜毛细血管层（从视网膜色素上皮（RPE）下方30 µm开始，厚度为10 µm）后，采用Phansalkar方法对血流信号缺失进行分割。我们分析了血流信号缺失大小-频率直方图，以研究各组间血流信号缺失比例的差异。然后我们验证了抗VEGF玻璃体腔内注射治疗后各组间的差异。
结果
在PCV组和老年对照组的差异曲线上，在血流信号缺失大小为900至1125 µm范围内出现一个峰值。老年对照组中900至1125 µm血流信号缺失大小的平均数显著高于青年对照组（P<0.05），患眼组与老年对照组之间无差异。患眼组中900至1125 µm血流信号缺失大小的比例显著高于老年对照组（P<0.05），青年对照组与老年对照组之间无差异。治疗后治疗组中900至1125 µm血流信号缺失大小平均数及900至1125 µm血流信号缺失大小比例均显著升高（P<0.05），治疗组的对侧眼无差异。治疗组治疗后脉络膜厚度显著降低（P<0.001），而治疗组的对侧眼无差异。
结论
我们的方法对PCV患眼、对侧眼以及抗VEGF治疗后患眼的脉络膜毛细血管结构的病理变化具有特异性。
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