An Young-Sil, Kim Se-Hyuk, Roh Tae Hoon, Park So Hyun, Kim Tae-Gyu, Kim Jang-Hee
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, South Korea.
Department of Neurosurgery, Ajou University School of Medicine, Suwon, South Korea.
Front Oncol. 2021 Jun 24;11:618705. doi: 10.3389/fonc.2021.618705. eCollection 2021.
The purpose of this study was to investigate the correlation between F-fluorodeoxyglucose (FDG) uptake and infiltrating immune cells in metastatic brain lesions.
This retrospective study included 34 patients with metastatic brain lesions who underwent brain F-FDG positron emission tomography (PET)/computed tomography (CT) followed by surgery. F-FDG uptake ratio was calculated by dividing the standardized uptake value (SUV) of the metastatic brain lesion by the contralateral normal white matter uptake value. We investigated the clinicopathological characteristics of the patients and analyzed the correlation between F-FDG uptake and infiltration of various immune cells. In addition, we evaluated immune-expression levels of glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and Ki-67 in metastatic brain lesions.
The degree of F-FDG uptake of metastatic brain lesions was not significantly correlated with clinical parameters. There was no significant relationship between the F-FDG uptake and degree of immune cell infiltration in brain metastasis. Furthermore, other markers, such as GLUT1, HK2, and Ki-67, were not correlated with degree of F-FDG uptake. In metastatic brain lesions that originated from breast cancer, a higher degree of F-FDG uptake was observed in those with high expression of CD68.
In metastatic brain lesions, the degree of F-FDG uptake was not significantly associated with infiltration of immune cells. The F-FDG uptake of metastatic brain lesions from breast cancer, however, might be associated with macrophage activity.
本研究旨在探讨氟脱氧葡萄糖（FDG）摄取与脑转移瘤中浸润免疫细胞之间的相关性。
这项回顾性研究纳入了34例脑转移瘤患者，这些患者在接受脑部F-FDG正电子发射断层扫描（PET）/计算机断层扫描（CT）后接受了手术。FDG摄取率通过将脑转移瘤的标准化摄取值（SUV）除以对侧正常白质摄取值来计算。我们调查了患者的临床病理特征，并分析了FDG摄取与各种免疫细胞浸润之间的相关性。此外，我们评估了脑转移瘤中葡萄糖转运蛋白1（GLUT1）、己糖激酶2（HK2）和Ki-67的免疫表达水平。
脑转移瘤的FDG摄取程度与临床参数无显著相关性。脑转移中FDG摄取与免疫细胞浸润程度之间无显著关系。此外，其他标志物，如GLUT1、HK2和Ki-67，与FDG摄取程度无关。在源自乳腺癌的脑转移瘤中，CD68高表达者观察到更高程度的FDG摄取。
在脑转移瘤中，FDG摄取程度与免疫细胞浸润无显著相关性。然而，源自乳腺癌的脑转移瘤的FDG摄取可能与巨噬细胞活性有关。
