从果实中分离得到的类黄酮糖苷及其抗氧化和 -葡萄糖苷酶抑制活性。
Flavonoid glycosides from the fruits of and their anti-oxidant and -glucosidase inhibitory activities.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tianjin Key Laboratory of TCM Quality Markers, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
出版信息
J Asian Nat Prod Res. 2021 Aug;23(8):724-730. doi: 10.1080/10286020.2020.1776266. Epub 2020 Jun 17.
Three new flavonoid glycosides, embeliaflavosides A-C (), together with eight known flavonoid glycosides (), were isolated from the fruits of . Their structures were established based on the analyses of spectroscopic data. Compounds were evaluated for antioxidant and -glucosidase inhibitory activities. The results revealed that compounds owned significant ABTS radical scavenging activity with IC values of 2.52-9.78 µM, and DPPH scavenging activity with IC values of 7.56-26.47 µM, respectively. However, -glucosidase inhibition assay indicated that all the isolates were inactive.[Formula: see text].
从八角茴香的果实中分离得到 3 个新的黄酮苷类化合物，即八角茴香苷 A-C()，以及 8 个已知的黄酮苷类化合物()。基于光谱数据分析确定了它们的结构。对化合物进行了抗氧化和 -葡萄糖苷酶抑制活性评价。结果表明，化合物具有显著的 ABTS 自由基清除活性，IC 值为 2.52-9.78 μM，DPPH 清除活性，IC 值为 7.56-26.47 μM。然而，-葡萄糖苷酶抑制试验表明，所有分离得到的化合物均无活性。
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