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-体外和计算机模拟研究：-叶片的化学成分及α-葡萄糖苷酶抑制活性

Chemical Constituents and -Glucosidase Inhibitory Activities of the Leaves of -In Vitro and In Silico Studies.

作者信息

Thuong Sy Danh, Anh Mai Thi Hoang, Phuong Nguyen Van, Mau Chu Hoang, Quan Nguyen Huu, Cong Nguyen Thanh, Thanh Le Nguyen

机构信息

Faculty of Biology, Thai Nguyen University of Education, Thai Nguyen University, Thai Nguyen 250000, Vietnam.

Department of Pharmacognosy, Faculty of Pharmacognosy and Traditional Medicine, Hanoi University of Pharmacy, Hanoi 10000, Vietnam.

出版信息

Life (Basel). 2025 Apr 22;15(5):680. doi: 10.3390/life15050680.

DOI:10.3390/life15050680
PMID:40430109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12112773/
Abstract

Phytochemical investigation of the methanol extract of Wall. Ex A. DC. leaves (Primulaceae family) led to the isolation of sixteen compounds including three sterols (-), one triterpene (), four flavonoids (-), four megastigmanes (-), three phenolic compounds (-), and one furan derivative (). Their chemical structures were determined based on ESI-MS and NMR spectral data. This is the first chemical study of . Compounds , -, and were found in the genus for the first time. Compounds -, , and represent the first isolation from the Primulaceae family. In the -glucosidase activity assay, MeOH extract, compounds and strongly inhibited enzyme -glucosidase activity. A molecular docking study revealed that compounds and showed different interactions with enzyme -glucosidase.

摘要

对报春花科植物Wall. Ex A. DC.叶的甲醇提取物进行植物化学研究，从中分离出16种化合物，包括三种甾醇（-）、一种三萜（）、四种黄酮类化合物（-）、四种巨大戟烷型二萜（-）、三种酚类化合物（-）和一种呋喃衍生物（）。根据电喷雾电离质谱（ESI-MS）和核磁共振（NMR）光谱数据确定了它们的化学结构。这是对……的首次化学研究。化合物……、……和……首次在……属中被发现。化合物……、……和……是首次从报春花科中分离得到。在α-葡萄糖苷酶活性测定中，甲醇提取物、化合物……和……强烈抑制α-葡萄糖苷酶的活性。分子对接研究表明，化合物……和……与α-葡萄糖苷酶表现出不同的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/837f36a1d672/life-15-00680-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/2817ddf82edf/life-15-00680-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/48051ae9ef6a/life-15-00680-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/837f36a1d672/life-15-00680-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/2817ddf82edf/life-15-00680-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/48051ae9ef6a/life-15-00680-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aae2/12112773/837f36a1d672/life-15-00680-g003.jpg

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