局部 5-氨基酮戊酸光动力疗法治疗扁平疣：6 例报告。
Topical 5-aminolevulinic acid photodynamic therapy in the treatment of verruca plana: Report of 6 cases.
机构信息
Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.; Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University; The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.; Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen 518020, Guangdong, China.
Department of Dermatology, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.
出版信息
Photodiagnosis Photodyn Ther. 2021 Sep;35:102438. doi: 10.1016/j.pdpdt.2021.102438. Epub 2021 Jul 10.
Verruca plana, also known as flat wart, is a common viral skin infection by human papillomavirus types 3, 10, 28 and 41. It's mostly prevalent on the facial area of children and young adults, becoming a heavy cosmetic burden on these patients. In this study, we report 6 cases of verruca plana predominantly affecting the visage, which are treated with 10% 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). In general, all 6 patients showed complete clearance of lesions 1 month after treatment. And clearance of lesions sustained in 4 out of 6 patients for at least 12 months after treatment. The results of this study suggest that ALA-PDT could be an effective treatment modality for verruca plana, especially for cases recalcitrant to other treatments. Nevertheless, more measures should be taken to prevent PDT-related adverse events.
扁平疣，又称平疣，是一种由人乳头瘤病毒 3、10、28 和 41 型引起的常见病毒性皮肤感染。它主要发生在儿童和青年的面部，给这些患者带来沉重的美容负担。在这项研究中，我们报告了 6 例主要影响面部的扁平疣病例，这些病例采用了 10% 5-氨基酮戊酸基光动力疗法（ALA-PDT）进行治疗。总的来说，所有 6 例患者在治疗后 1 个月均显示皮损完全清除。在 6 例患者中，有 4 例至少在治疗后 12 个月内皮损持续清除。本研究结果表明，ALA-PDT 可能是治疗扁平疣的有效方法，尤其是对其他治疗方法有抵抗力的病例。然而，应该采取更多措施来预防 PDT 相关的不良反应。
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