Mazur Anna, Koziorowska Katarzyna, Dynarowicz Klaudia, Aebisher David, Bartusik-Aebisher Dorota
Students Biochemistry Science Club URCell, Medical College of the University of Rzeszów, 35-959 Rzeszów, Poland.
Students English Division Science Club, Medical College of the University of Rzeszów, 35-959 Rzeszów, Poland.
Children (Basel). 2022 May 10;9(5):695. doi: 10.3390/children9050695.
Photodynamic therapy is a mode of treatment whereby local irradiation of an administered photosensitizer with light of a specific wavelength generates cytotoxic reactive oxygen species. Despite the upward trend in the popularity of this method in adults, it is not yet commonly used in the treatment of children. Due to certain limitations, underdeveloped treatment regimens and potential side effects, the use of photodynamic therapy in the pediatric population is still in the initial phases of evaluation in clinical trials.
This study is a review of articles in English from the databases PubMed and Web of Science retrieved by applying the search term "photodynamic therapy in children" from 2000-2020.
Based on the literature review, we analyze selected pediatric clinical cases in which photodynamic therapy was used for treatment in children. Examples of photodynamic therapy for treatment of dermatological diseases, diseases of the mucosa of the upper respiratory tract, halitosis, eye diseases and brain tumors are described. The paper describes the effectiveness of anti-cancer photodynamic therapy, including its use in antibacterial therapy.
The results of the analysis suggest the potential of photodynamic therapy for the treatment of various diseases in children.
光动力疗法是一种治疗方式，即对局部施用的光敏剂用特定波长的光进行照射，从而产生活细胞毒性的活性氧。尽管这种方法在成人中的受欢迎程度呈上升趋势，但它尚未普遍用于儿童治疗。由于某些局限性、治疗方案不完善以及潜在的副作用，光动力疗法在儿科人群中的应用仍处于临床试验评估的初始阶段。
本研究是对2000年至2020年期间从PubMed和Web of Science数据库中检索到的英文文章进行综述，检索词为“儿童光动力疗法”。
基于文献综述，我们分析了使用光动力疗法治疗儿童的选定儿科临床病例。描述了光动力疗法用于治疗皮肤病、上呼吸道黏膜疾病、口臭、眼部疾病和脑肿瘤的实例。本文还描述了抗癌光动力疗法的有效性，包括其在抗菌治疗中的应用。
分析结果表明光动力疗法在治疗儿童各种疾病方面具有潜力。
