Department of Microbiology, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea.
Virology. 2021 Oct;562:40-49. doi: 10.1016/j.virol.2021.06.011. Epub 2021 Jul 5.
Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
多种自然宿主携带的副黏病毒对公共卫生构成潜在威胁。杰氏病毒被认为是一种新型副黏病毒属，存在于啮齿动物、蝙蝠和猫中。在韩国的 14 个诱捕点捕获的 824 只艾氏田鼠中，有 108 只（13.1%）检测到副黏病毒 RNA。我们首次发现了两种具有遗传差异的新型副黏病毒，Paju Apodemus 副黏病毒 1（PAPV-1）和 2（PAPV-2）。PAPV-1（19716 个核苷酸）和 -2（17475 个核苷酸）之间的差异表明基因组结构中存在 SH 基因和 G 基因的长度。PAPV-1 和 -2 的系统发育分别属于杰氏病毒的不同遗传谱系，尽管这些病毒起源于艾氏田鼠。PAPV-1 感染人上皮细胞和内皮细胞，促进 I/III 型干扰素、干扰素刺激基因和促炎细胞因子的诱导。因此，本研究为新型啮齿动物携带的副黏病毒的分子流行病学、遗传多样性和病毒-宿主相互作用提供了见解。
