Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, CH-9007 St. Gallen, Switzerland; and.
Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, CH-9007 St. Gallen, Switzerland; and
J Immunol. 2021 Jan 15;206(2):257-263. doi: 10.4049/jimmunol.2000914.
Stromal cells have for a long time been viewed as structural cells that support distinct compartments within lymphoid tissues and little more. Instead, an active cross-talk between endothelial and fibroblastic stromal cells drives the maturation of lymphoid niches, a relationship that is recapitulated during lymph node organogenesis, steady-state conditions, and following inflammation. In this review, we go over recent advances in genetic models and high-resolution transcriptomic analyses that have propelled the finer resolution of the stromal cell infrastructure of lymph nodes, revealing that the distinct subsets are strategically positioned to deliver a catered mixture of niche factors to interacting immune cell populations. Moreover, we discuss how changes in the activation state of poised stromal cell-underpinned niches rather than on-demand differentiation of new stromal cell subsets govern the efficient interaction of Ag, APC, and cognate B and T lymphocytes during adaptive immune responses.
基质细胞长期以来一直被视为支持淋巴组织内不同隔室的结构性细胞，除此之外别无他用。相反，内皮细胞和纤维母细胞基质细胞之间的活跃串扰驱动着淋巴龛的成熟，这种关系在淋巴结器官发生、稳态条件下以及炎症后都得到了再现。在这篇综述中，我们回顾了遗传模型和高分辨率转录组分析的最新进展，这些进展推动了对淋巴结基质细胞基础设施的更精细分辨率的研究，揭示了不同亚群的战略定位，以提供定制的龛位因子混合物，以与相互作用的免疫细胞群体进行交流。此外，我们还讨论了如何改变处于激活状态的基质细胞所支撑的龛位，而不是按需分化新的基质细胞亚群，来控制抗原、抗原呈递细胞和同源 B 和 T 淋巴细胞在适应性免疫反应中的有效相互作用。
