Department of Urology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Department of Pathology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Pathol Oncol Res. 2021 Mar 26;27:528050. doi: 10.3389/pore.2021.528050. eCollection 2021.
Herein we present a previously unreported rare case of mucinous adenocarcinoma arising from a congenital ejaculatory duct cyst. Radiographic and endoscopic examinations revealed the tumor occurred in a cyst running through the prostate. Initially, the immunohistochemical pathology results showed that it was a metastatic mucinous adenocarcinoma, but no other primary lesions were clinically evidenced. Based on the embryonic development process of the male urogenital tract, the malformation of the patient's ejaculatory duct, and the pathological examination of the resected specimen, we considered the tumor to be a primary mucinous adenocarcinoma which originating from the hypoplastic ejaculatory duct. The tumor may have developed from the foci of intestinal metaplasia from cloacal remnants during embryonic development.
在此，我们报告一例罕见的先天性射精管囊肿来源的黏液性腺癌。影像学和内镜检查显示肿瘤发生于贯穿前列腺的囊肿内。最初，免疫组化病理结果显示为转移性黏液性腺癌，但临床未发现其他原发灶。基于男性尿生殖嵴的胚胎发育过程、患者射精管的畸形以及切除标本的病理检查，我们认为肿瘤为来源于发育不良的射精管的原发性黏液性腺癌。肿瘤可能来源于胚胎发育过程中泄殖腔残余的肠上皮化生灶。
