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前纵隔原发性黏液腺癌伴基因突变:一例罕见病例报告

Primary mucinous adenocarcinoma of the anterior mediastinum with mutation: A rare case report.

作者信息

Zhang Yu, Rui Jinqiu, Liang Jun, Lin Li

机构信息

Department of Oncology Center, Peking University International Hospital, Life Park Road, Zhong Guancun Life Science Park, Changping District, Beijing, 102206, China.

Department of Medicine, Geneplus-Beijing, Beijing, 102206, China.

出版信息

Heliyon. 2024 Jul 9;10(14):e34346. doi: 10.1016/j.heliyon.2024.e34346. eCollection 2024 Jul 30.

Abstract

We report the case of a 68-year-old male whose Computed Tomography (CT) scan presented a mass (686254 mm) of the right anterior mediastinal and pathologically diagnosis was mucinous adenocarcinoma(MA). The peripheral vessels are surrounded by the big mass in the anterior mediastinum which was associated with multiple metastases, thus we performed palliative chemoradiotherapy and we tried Human Epidermal Growth Factor Receptor-2 (HER-2) inhibitors based on the Next Generation Sequencing. The patient passed away 16 months after the onset of the disease. In this report, we review the rare case of anterior mediastinum MA as well as perspectives for potential future treatments.

摘要

我们报告了一例68岁男性患者,其计算机断层扫描(CT)显示右前纵隔有一个肿块(68×62×54mm),病理诊断为黏液腺癌(MA)。前纵隔的大肿块包绕着周围血管,并伴有多处转移,因此我们进行了姑息性放化疗,并根据下一代测序结果尝试使用人表皮生长因子受体2(HER-2)抑制剂。患者在疾病发作16个月后去世。在本报告中,我们回顾了前纵隔MA这一罕见病例以及未来潜在治疗的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/67e9a9379cad/gr1.jpg

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