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前纵隔原发性黏液腺癌伴基因突变:一例罕见病例报告

Primary mucinous adenocarcinoma of the anterior mediastinum with mutation: A rare case report.

作者信息

Zhang Yu, Rui Jinqiu, Liang Jun, Lin Li

机构信息

Department of Oncology Center, Peking University International Hospital, Life Park Road, Zhong Guancun Life Science Park, Changping District, Beijing, 102206, China.

Department of Medicine, Geneplus-Beijing, Beijing, 102206, China.

出版信息

Heliyon. 2024 Jul 9;10(14):e34346. doi: 10.1016/j.heliyon.2024.e34346. eCollection 2024 Jul 30.

DOI:10.1016/j.heliyon.2024.e34346
PMID:39100453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11295853/
Abstract

We report the case of a 68-year-old male whose Computed Tomography (CT) scan presented a mass (686254 mm) of the right anterior mediastinal and pathologically diagnosis was mucinous adenocarcinoma(MA). The peripheral vessels are surrounded by the big mass in the anterior mediastinum which was associated with multiple metastases, thus we performed palliative chemoradiotherapy and we tried Human Epidermal Growth Factor Receptor-2 (HER-2) inhibitors based on the Next Generation Sequencing. The patient passed away 16 months after the onset of the disease. In this report, we review the rare case of anterior mediastinum MA as well as perspectives for potential future treatments.

摘要

我们报告了一例68岁男性患者,其计算机断层扫描(CT)显示右前纵隔有一个肿块(68×62×54mm),病理诊断为黏液腺癌(MA)。前纵隔的大肿块包绕着周围血管,并伴有多处转移,因此我们进行了姑息性放化疗,并根据下一代测序结果尝试使用人表皮生长因子受体2(HER-2)抑制剂。患者在疾病发作16个月后去世。在本报告中,我们回顾了前纵隔MA这一罕见病例以及未来潜在治疗的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/7b691cffc8f6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/67e9a9379cad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/577be84d3f55/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/7b691cffc8f6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/67e9a9379cad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/577be84d3f55/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f359/11295853/7b691cffc8f6/gr3.jpg

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本文引用的文献

1
Lenvatinib-refractory thymic mucinous carcinoma with mutation.伴有突变的乐伐替尼难治性胸腺黏液癌
Int Cancer Conf J. 2022 Aug 20;12(1):36-40. doi: 10.1007/s13691-022-00573-8. eCollection 2023 Jan.
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The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.2021 年世卫组织肺肿瘤分类:自 2015 年以来的进展影响。
J Thorac Oncol. 2022 Mar;17(3):362-387. doi: 10.1016/j.jtho.2021.11.003. Epub 2021 Nov 20.
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Trastuzumab Deruxtecan in -Mutant Non-Small-Cell Lung Cancer.曲妥珠单抗 deruxtecan 治疗 - 突变型非小细胞肺癌。
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Primary mucinous adenocarcinoma of the thymus: A case report.胸腺原发性黏液腺癌:一例报告
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Case Report: Mucinous Adenocarcinoma Arising From Congenital Ejaculatory Duct Cyst.病例报告:先天性射精管囊腺瘤恶变黏液性腺癌。
Pathol Oncol Res. 2021 Mar 26;27:528050. doi: 10.3389/pore.2021.528050. eCollection 2021.
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Primary mucinous adenocarcinoma of the thymus; a rare type of thymic carcinoma. Case Report.胸腺原发性黏液腺癌;一种罕见的胸腺癌。病例报告。
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