Key Laboratory of Xinjiang Metabolic Disease, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Departments of Occupational and Environmental Health, Xinjiang Medical University, Urumqi 830054, China.
Biomed Res Int. 2021 Jun 26;2021:6646750. doi: 10.1155/2021/6646750. eCollection 2021.
The aim of this study was to investigate the correlation between polymorphisms in the FTO gene and TSH level in Uyghur patients with type 2 diabetes in the Xinjiang region. . This cohort was made up of 498 Uyghur patients with type 2 diabetes who underwent genotype screening for rs8050136 and rs9939609 using the Sequenom MassARRAY system. The distribution frequencies of the genotypes and alleles at rs8050136 and rs993960 were compared between two patient groups, those with TSH < 2.5 mU/L and those with TSH ≥ 2.5 mU/L group. We further evaluated the relationships between these different genotypes and FT3, FT4, TSH, FPG, and HbA1c expression.
The results suggested the TSH level was 2.281 times higher in rs8050136 CC+CA carriers than in AA genotype (95%CI = 1.0245.080, = 0.044) and was 2.417 times higher in rs9939609 TT+TA carriers than in AA genotype (95%CI = 1.2574.649, = 0.008) after adjusting for age, sex, and BMI under the recessive model. TSH levels were significantly different between T2DM patients with different FTO genotypes, rs8050136 ( = 0.008) and rs9939609 ( = 0.003), with TSH levels in rs8050136 CC genotype carriers showing a significant increase compared to those in the AA genotype carriers ( = 0.005). Additionally, rs9939609 TT and TA genotype carriers had a significant increase in the TSH level when compared to AA genotype carriers ( = 0.001 and = 0.031, respectively). The TSH level was also significantly different in these male patients with different genotypes of rs8050136 ( = 0.026) and rs9939609 ( = 0.019). And TSH levels in rs8050136 CC genotype male carriers showing a significant increase compared to those in the AA genotype carriers ( = 0.013) and rs9939609 TT genotype male carriers had a significant increase in TSH level when compared to AA genotype carriers ( = 0.004).
The polymorphisms at rs8050136 and rs9939609 are associated with changes in the TSH level with rs8050136 CC and rs9939609 TT genotypes identified as potential risk factors for increased TSH levels in these male patients.
本研究旨在探讨 FTO 基因多态性与新疆维吾尔族 2 型糖尿病患者 TSH 水平的相关性。。该队列由 498 名维吾尔族 2 型糖尿病患者组成，采用 Sequenom MassARRAY 系统对 rs8050136 和 rs9939609 进行基因型筛查。比较了 TSH < 2.5 mU/L 和 TSH ≥ 2.5 mU/L 两组患者 rs8050136 和 rs993960 基因型和等位基因的分布频率。我们进一步评估了这些不同基因型与 FT3、FT4、TSH、FPG 和 HbA1c 表达之间的关系。
结果表明，在隐性模型下，rs8050136 CC+CA 携带者的 TSH 水平比 AA 基因型高 2.281 倍（95%CI = 1.0245.080， = 0.044），rs9939609 TT+TA 携带者的 TSH 水平比 AA 基因型高 2.417 倍（95%CI = 1.2574.649， = 0.008）。在调整年龄、性别和 BMI 后，2 型糖尿病患者的 TSH 水平在不同的 FTO 基因型之间存在显著差异，rs8050136（ = 0.008）和 rs9939609（ = 0.003），rs8050136 CC 基因型携带者的 TSH 水平明显高于 AA 基因型携带者（ = 0.005）。此外，rs9939609 TT 和 TA 基因型携带者的 TSH 水平与 AA 基因型携带者相比有显著升高（ = 0.001 和 = 0.031）。在这些不同基因型的男性患者中，rs8050136（ = 0.026）和 rs9939609（ = 0.019）的 TSH 水平也存在显著差异。与 AA 基因型携带者相比，rs8050136 CC 基因型男性携带者的 TSH 水平显著升高（ = 0.013），rs9939609 TT 基因型男性携带者的 TSH 水平也显著升高（ = 0.004）。
rs8050136 和 rs9939609 多态性与 TSH 水平的变化相关，rs8050136 CC 和 rs9939609 TT 基因型可能是这些男性患者 TSH 水平升高的潜在危险因素。
