Pharmacology Department Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan.
Pharmacology Department Riphah International University, Islamabad, Pakistan.
J Diabetes Res. 2024 Sep 2;2024:5914316. doi: 10.1155/2024/5914316. eCollection 2024.
The role of the common FTO gene variant rs9939609 in obesity has been well established, and the FTO gene has a strong association with T2DM. To investigate the association of FTO gene variant rs9939609 with obesity-related parameters in T2DM and CVD patients. In this cross-sectional study, 280 subjects of either sex aged 45.10 ± 9.6 years were randomly divided into four groups, that is, T2DM, T2DM with CVD, nondiabetic with CVD disease, and normal control. These samples were genotyped by ARMS-PCR. The FTO gene association with obesity-related parameters in T2DM and CVD patients was analyzed by SPSS 22. The TT genotype was the most common genotype (46.80%) in our study groups. The minor allele frequency (MAF) was significantly higher in T2DM patients (0.39 vs. 0.28), T2DM patients with CVD (0.43 vs. 0.28), and nondiabetic patients with CVD (0.35 vs. 0.28) as compared to control with < 0.005. Carriers of the AA genotype of the FTO gene rs9939609 were significantly associated with increased BMI, WC, HbA1C, SBP, DBP, and TGs and lowered HDL cholesterol as compared to the TA and TT genotypes in T2DM and CVD patients with < 0.005. The FTO gene variant rs9939609 showed a significant association with T2DM and CVD. The AA genotype odds ratio (OR) in T2DM was 1.48 (1.06-2.32), = 0.006, and in CVD, it was 1.56 (1.04-2.4), = 0.003. The FTO gene variant rs9939609 has a strong association with T2DM and CVD. The AA genotype of FTO gene variants rs9939609 showed a strong association with most of the risk factors of CVD and T2DM.
常见的 FTO 基因变异 rs9939609 与肥胖的关系已经得到充分证实，FTO 基因与 T2DM 有很强的关联。本研究旨在探讨 FTO 基因变异 rs9939609 与 T2DM 和 CVD 患者肥胖相关参数的关系。本横断面研究共纳入 280 名年龄 45.10±9.6 岁的受试者，按性别分为四组，即 T2DM 组、T2DM 合并 CVD 组、无糖尿病合并 CVD 组和正常对照组。采用 ARMS-PCR 法对样本进行基因分型。采用 SPSS 22 软件分析 FTO 基因与 T2DM 和 CVD 患者肥胖相关参数的关系。结果显示，TT 基因型是本研究中最常见的基因型（46.80%）。与对照组相比，T2DM 患者（0.39 比 0.28）、T2DM 合并 CVD 患者（0.43 比 0.28）和无糖尿病合并 CVD 患者（0.35 比 0.28）的 FTO 基因 rs9939609 等位基因频率（MAF）显著升高，均 ＜0.005。与 TA 和 TT 基因型相比，FTO 基因 rs9939609 的 AA 基因型携带者的 BMI、WC、HbA1C、SBP、DBP 和 TG 显著升高，HDL 胆固醇显著降低，均 ＜0.005。FTO 基因 rs9939609 与 T2DM 和 CVD 显著相关。T2DM 患者 AA 基因型的优势比（OR）为 1.48（1.06-2.32），=0.006；CVD 患者的 OR 为 1.56（1.04-2.4），=0.003。FTO 基因 rs9939609 与 T2DM 和 CVD 密切相关。FTO 基因 rs9939609 的 AA 基因型与 CVD 和 T2DM 的大多数危险因素密切相关。
