Wang Yanqing, Guo Ying
Ackerman Academy of Dermatopathology, New York, New York, USA.
Department of Dermatology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
J Cutan Pathol. 2021 Dec;48(12):1493-1496. doi: 10.1111/cup.14096. Epub 2021 Jul 29.
Melanoma may mimic a variety of skin lesions clinically and histopathologically, and presents diagnostic challenges. In this article, we describe a case of melanoma in an 89-year-old man with a very rare histopathologic presentation, namely the presence of pleomorphic and multinucleated giant cells with abundant cytoplasm, highly resembling an atypical fibroxanthoma. The differential diagnoses in conjunction with the findings in immunohistochemical study are also discussed.
黑色素瘤在临床和组织病理学上可能会模仿多种皮肤病变，从而带来诊断挑战。在本文中，我们描述了一例89岁男性黑色素瘤病例，其具有非常罕见的组织病理学表现，即存在具有丰富细胞质的多形性和多核巨细胞，与非典型纤维黄色瘤极为相似。同时还讨论了结合免疫组化研究结果进行的鉴别诊断。
