钯催化功能化异氰的酰基环化反应构建 N-杂环化合物的研究进展。
Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles.
机构信息
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China.
State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China and University of Chinese Academy of Sciences, Beijing 100049, China and Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China.
出版信息
Org Biomol Chem. 2021 Aug 11;19(31):6730-6745. doi: 10.1039/d1ob00864a.
Palladium-catalysed isocyanide insertion reactions have witnessed great progress in recent years. In particular, imidoylative cyclization of functionalized isocyanides was successfully developed by taking advantage of the adjustable substituents on the isocyano group, opening a new avenue to access a variety of nitrogen-containing heterocycles. In this review article, we summarize the advances of functionalized isocyanide insertion reactions and highlight the breakthroughs of enantioselective palladium catalysed imidoylation reactions by using this strategy. Additionally, copper-catalysed cyclization reactions of functionalized isocyanides are briefly discussed.
钯催化的异氰化物插入反应近年来取得了重大进展。特别是，通过利用异氰基上可调节的取代基，成功开发了功能化异氰化物的酰亚胺化环化反应，为构建各种含氮杂环开辟了新途径。在这篇综述文章中，我们总结了功能化异氰化物插入反应的进展，并强调了利用该策略实现对映选择性钯催化酰亚胺化反应的突破。此外，还简要讨论了功能化异氰化物的铜催化环化反应。
Zotero 插件