Department of Biomechanics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Artificial Joints and Biomaterials, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
J Med Ultrason (2001). 2021 Oct;48(4):631-638. doi: 10.1007/s10396-021-01109-y. Epub 2021 Jul 14.
This study aimed to investigate the association between the severity of medial meniscus extrusion (MME) under weight bearing and pain in patients with early-stage knee osteoarthritis (OA).
Twenty-eight patients with symptomatic early-stage knee OA (Kellgren and Lawrence grade ≤ 2) who visited our outpatient clinic between 2016 and 2018 were included in this cross-sectional study (mean age: 58.0 ± 11.6 years, female: n = 10). MME was evaluated under weight-bearing conditions using ultrasonography. Patients were divided into two groups according to the severity of MME under weight bearing: those with MME ≥ 3 mm were assigned to the severe group, whereas those with MME < 3 mm were assigned to the mild group. The knee injury osteoarthritis outcome score (KOOS) system was used to evaluate knee pain. The incidence of bone marrow lesions (BMLs) was evaluated using magnetic resonance images.
The KOOS pain score was significantly lower in the severe group than in the mild group (P < 0.05). The incidence of BMLs was significantly higher in the severe group (69%) than in the mild group (7%) (P < 0.001).
Patients with early-stage knee OA who have greater MME under weight-bearing have more intense knee pain and a higher incidence of BMLs.
本研究旨在探讨在负重状态下内侧半月板后角(MME)外突程度与早期膝关节骨关节炎(OA)患者疼痛之间的关系。
本横断面研究纳入了 2016 年至 2018 年间在我院门诊就诊的 28 例有症状的早期膝关节 OA(Kellgren 和 Lawrence 分级≤2)患者(平均年龄:58.0±11.6 岁,女性:n=10)。采用超声检查评估负重下 MME 的严重程度。根据负重下 MME 的严重程度将患者分为两组:MME≥3mm 为重度组,MME<3mm 为轻度组。采用膝关节损伤骨关节炎结局评分(KOOS)系统评估膝关节疼痛。采用磁共振成像(MRI)评估骨髓病变(BML)的发生率。
重度组的 KOOS 疼痛评分显著低于轻度组(P<0.05)。重度组的 BML 发生率(69%)显著高于轻度组(7%)(P<0.001)。
在负重状态下 MME 较大的早期膝关节 OA 患者膝关节疼痛更剧烈,BML 的发生率更高。