新西兰眼表鳞状细胞肿瘤：怀卡托地区十年发病率回顾。

Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region.

机构信息

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Department of Ophthalmology, Waikato District Health Board, Hamilton, New Zealand.

出版信息

Eye (Lond). 2022 Aug;36(8):1567-1570. doi: 10.1038/s41433-021-01662-3. Epub 2021 Jul 14.

DOI:10.1038/s41433-021-01662-3

PMID:34262162

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9307772/

Abstract

BACKGROUND

Ocular surface squamous neoplasia (OSSN) is a relatively rare disease with a low mortality and highly variable incidence. Despite a high incidence of OSSN in the Southern hemisphere, there is limited epidemiological data for New Zealand. The current study aims to assess the incidence, demographics, and histological grade of OSSN in the Waikato region of New Zealand, home to ~10% of the population of New Zealand.

METHODS

Non-interventional retrospective cohort study. All conjunctival biopsy histology reports from 2010 to 2019 in the Waikato region of New Zealand were analysed. Age, sex, and ethnicity were analysed and the incidence of OSSN was calculated. Main outcome measures included histological grade, rate of recurrence, and incidence of OSSN.

RESULTS

A total of 386 patients underwent conjunctival biopsy with histology during the study period. Eighty-three lesions (22%) involving 80 patients (21%) were reported positive for OSSN. Patients with OSSN had a mean age of 68.9 years (SD = 13.2), were predominantly male (76%), and of New Zealand-European ethnicity (53%). Conjunctival intraepithelial neoplasia-1 (30%) was the most frequent diagnosis. Three patients (4%) had recurrent lesions requiring repeat biopsy. The peak annual OSSN incidence rate was 3.81/100,000 population in 2019. The overall ten-year incidence was 2.13/100,000 population/year.

CONCLUSION

This is the largest study to investigate OSSN incidence in New Zealand. The incidence rate of OSSN is one of the highest rates reported in the literature.

摘要

背景

眼表面鳞状上皮肿瘤（OSSN）是一种相对罕见的疾病，其死亡率较低，发病率变化较大。尽管南半球 OSSN 的发病率较高，但新西兰的流行病学数据有限。本研究旨在评估新西兰怀卡托地区 OSSN 的发病率、人口统计学和组织学分级，该地区约占新西兰人口的 10%。

方法

非干预性回顾性队列研究。分析了 2010 年至 2019 年新西兰怀卡托地区的所有结膜活检组织学报告。分析了年龄、性别和种族，并计算了 OSSN 的发病率。主要观察指标包括组织学分级、复发率和 OSSN 发病率。

结果

在研究期间，共有 386 例患者接受了结膜活检术。83 例（22%）涉及 80 例（21%）患者的病变组织学报告为 OSSN 阳性。患有 OSSN 的患者平均年龄为 68.9 岁（标准差=13.2），主要为男性（76%），且为新西兰欧洲裔（53%）。最常见的诊断是结膜上皮内瘤变 1 级（30%）。有 3 例（4%）患者的病变复发，需要再次活检。2019 年 OSSN 的年发病率峰值为 3.81/10 万，总十年发病率为 2.13/10 万/年。