Hossain Ruhella R, Oh Jee Ah, McLintock Cameron, Murphy Chris, McKelvie James
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand.
Department of Ophthalmology, Hawkes Bay District Health Board, Hastings 4120, New Zealand.
Vision (Basel). 2022 Aug 12;6(3):50. doi: 10.3390/vision6030050.
Ocular surface squamous neoplasia (OSSN) has a high incidence in the southern hemisphere. This prospective study evaluated the incidence of OSSN in the Waikato region of New Zealand. All patients presenting with pterygium or conjunctival lesions in the Waikato region in 2020 were included. All surgeons in the region were asked to send all conjunctival and corneal specimens excised for histopathologic examination. The primary outcome measure was the incidence of OSSN. Eighty-eight percent of all excised specimens were sent for histopathologic examination. Of the 185 excised lesions sent for histopathological assessment, 18 (10%) were reported as OSSN. Patients were on average 69.4 years of age (standard deviation, SD = 6.9), predominantly male (78%), and of New Zealand-European ethnicity (89%). The OSSN annual incidence was 3.67/100,000/year. Histology grades included conjunctival intraepithelial neoplasia (CIN)-I (25%), CIN-II (25%), CIN-III (12.5%), carcinoma in situ (25%), and invasive squamous cell carcinoma (SCC) (12.5%). One patient with invasive SCC required exenteration. This study identified a high incidence rate of OSSN and is the first prospective study to analyze OSSN epidemiology in New Zealand.
眼表鳞状上皮肿瘤（OSSN）在南半球发病率较高。这项前瞻性研究评估了新西兰怀卡托地区OSSN的发病率。纳入了2020年在怀卡托地区出现翼状胬肉或结膜病变的所有患者。该地区所有外科医生均被要求将所有切除的结膜和角膜标本送去做组织病理学检查。主要观察指标是OSSN的发病率。所有切除标本的88%被送去做组织病理学检查。在送去做组织病理学评估的185个切除病变中，有18个（10%）被报告为OSSN。患者平均年龄为69.4岁（标准差，SD = 6.9），以男性为主（78%），且为新西兰欧洲族裔（89%）。OSSN的年发病率为3.67/10万/年。组织学分级包括结膜上皮内瘤变（CIN）-I（25%）、CIN-II（25%）、CIN-III（12.5%）、原位癌（25%）和浸润性鳞状细胞癌（SCC）（12.5%）。1例浸润性SCC患者需要进行眼球摘除术。本研究确定了OSSN的高发病率，并且是第一项分析新西兰OSSN流行病学的前瞻性研究。
