Levine M M, Hughes T P, Simon P, O'Donnell S, Grauel S, Levine S G
J Infect Dis. 1977 Dec;136 Suppl:S571-4. doi: 10.1093/infdis/136.supplement_3.s571.
Single doses (50, 100, or 200 chick cell-agglutinating [CCA] units) of split-product or whole-virus (50 or 100 CCA units), monovalent inactivated A/New Jersey/8/76 (Hsw1n1) virus vaccine or placebo were given to healthy children aged three to five years in Maryland. Split-product vaccine was nonreactogenic but also virtually nonimmunogenic. Lower doses of whole-virus vaccine (50 CCA units of Merck, Sharp and Dohme [West Point, Pa.] and 50 or 100 CCA units of Merrell-National Laboratories [Cincinnati, Ohio] vaccine) were mildly reactogenic (approximately 25% of the children had low-grade fevers of 100 F-101 F). These dosage levels of whole-virus vaccine stimulated titers of greater than or equal to 1:20 in 68% and titers of greater than or equal to 1:40 in 37% of the children. Two inoculations of whole-virus vaccine (primary immunization followed by a booster one month later) were tolerated and induced titers of greater than or equal to 1:80 in 100% of the children.
向马里兰州3至5岁的健康儿童单剂量注射（50、100或200鸡细胞凝集[CCA]单位）裂解产物或全病毒（50或100 CCA单位）单价灭活A/新泽西/8/76（Hsw1n1）病毒疫苗或安慰剂。裂解产物疫苗无反应原性，但实际上也无免疫原性。较低剂量的全病毒疫苗（默克公司[宾夕法尼亚州西点市]的50 CCA单位以及梅里尔-国家实验室[俄亥俄州辛辛那提市]疫苗的50或100 CCA单位）有轻度反应原性（约25%的儿童出现100华氏度至101华氏度的低热）。这些剂量水平的全病毒疫苗在68%的儿童中刺激产生的滴度大于或等于1:20，在37%的儿童中刺激产生的滴度大于或等于1:40。对全病毒疫苗进行两次接种（初次免疫，一个月后加强接种），所有儿童均耐受，且100%的儿童诱导产生的滴度大于或等于1:80。
