Kumar Ashok, Ambiya Vikas, Mishra Sanjay Kumar, Jhanwar Mayank
Department of Ophthalmology, Armed Forces Medical College, Pune 411040, India.
Army College of Medical Sciences & Base Hospital, New Delhi, India; Command Hospital, Kolkata, India.
Ther Adv Ophthalmol. 2021 Jun 28;13:25158414211022875. doi: 10.1177/25158414211022875. eCollection 2021 Jan-Dec.
To evaluate changes in sub-foveal choroidal thickness in patients with acute idiopathic retinal vasculitis compared with age-matched healthy subjects and unaffected fellow eyes.
This prospective observational study included 36 eyes of 23 acute idiopathic retinal vasculitis patients (group V) which included a sub-group of 10 eyes of 10 patients with unilateral vasculitis (group UV), and 50 eyes of 25 healthy subjects (group N). The assessment involved demographics, systemic examination, comprehensive ocular examination, fundus photography with/without fundus fluorescein angiography, and spectral domain-optical coherence tomography with enhanced depth imaging.
There was significant difference between the mean sub-foveal choroidal thickness in groups V and N (V: 338.86 ± 28.72 um; N: 296.72 ± 19.45 μm; 0.001). The eyes of patients with unilateral vasculitis compared with unaffected fellow eyes had no significant difference in best corrected visual acuity (group UV: median = 0.2; range = (0.0-0.3) and group N: median = 0.2; range = (0.0-0.3); = 0.35) but the sub-foveal choroidal thickness was significantly increased in the involved eye (group UV: 333.5 ± 16.68 um; group N: 284.4 ± 15.68 um; 0.001). The BCVA was significantly lower in the eyes with anterior chamber inflammation (median = 0.2; range = (0.0-0.3) and; median = 0.1; range (0.0-0.3); = 0.002), but there was no statistically significant difference in sub-foveal choroidal thickness measurement between the two groups of vasculitis patients with and without anterior chamber inflammation (334.3 ± 18.85 um and 336 ± 31.56 um; = 0.22).
The sub-foveal choroidal thickness increases during active inflammation in eyes with idiopathic retinal vasculitis compared with unaffected fellow eyes and healthy control eyes. Thus, measurement of the sub-foveal choroidal thickness on optical coherence tomography with enhanced depth imaging can serve as a non-invasive modality in the diagnosis and monitoring of acute idiopathic retinal vasculitis.
评估急性特发性视网膜血管炎患者与年龄匹配的健康受试者及未受影响的对侧眼相比，黄斑中心凹下脉络膜厚度的变化。
这项前瞻性观察性研究纳入了23例急性特发性视网膜血管炎患者的36只眼（V组），其中包括10例单侧血管炎患者的10只眼的亚组（UV组），以及25例健康受试者的50只眼（N组）。评估包括人口统计学、全身检查、全面的眼部检查、有/无眼底荧光血管造影的眼底摄影，以及增强深度成像的光谱域光学相干断层扫描。
V组和N组的平均黄斑中心凹下脉络膜厚度之间存在显著差异（V组：338.86±28.72μm；N组：296.72±19.45μm；P<0.001）。单侧血管炎患者的患眼与未受影响的对侧眼相比，最佳矫正视力无显著差异（UV组：中位数=0.2；范围=(0.0 - 0.3)，N组：中位数=0.2；范围=(0.0 - 0.3)；P=0.35），但患眼中黄斑中心凹下脉络膜厚度显著增加（UV组：333.5±16.68μm；N组：284.4±15.68μm；P<0.001）。前房有炎症的眼中最佳矫正视力显著较低（中位数=0.2；范围=(0.0 - 0.3)，以及中位数=0.1；范围(0.0 - 0.3)；P=0.002），但有前房炎症和无前房炎症的两组血管炎患者之间黄斑中心凹下脉络膜厚度测量无统计学显著差异（334.3±18.85μm和336±31.56μm；P=0.22）。
与未受影响的对侧眼和健康对照眼相比，特发性视网膜血管炎患者的患眼在炎症活动期黄斑中心凹下脉络膜厚度增加。因此，利用增强深度成像的光学相干断层扫描测量黄斑中心凹下脉络膜厚度可作为急性特发性视网膜血管炎诊断和监测的一种非侵入性方法。
