Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Ann Palliat Med. 2021 Dec;10(12):12367-12373. doi: 10.21037/apm-21-3257.
To investigate the changes of subfoveal choroidal thickness (SFCT) and choriocapillary circulation in idiopathic macular holes (IMHs), the fellow eyes, and normal subjects using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA), and to explore the role of SFCT and choriocapillary circulation in the pathogenesis of IMH.
A case series of 30 patients with unilateral IMH and 30 subjects, with age- and sex-matched, were included. Thirty eyes of 30 patients with unilateral IMH, the unaffected fellow eyes, and 30 eyes of age- and sex-matched healthy patients were studied. SFCT was measured by spectral domain enhanced depth imaging optical coherence tomography (EDI SD-OCT), while vascular density and blood flow area of choriocapillary circulation were obtained by OCTA.
The SECT in IMH eyes (236.09±79.25 µm) was lower than that in the unaffected fellow eyes (249.71±86.10 µm) (P=0.040) and healthy control eyes (283.29±64.16 µm) (P=0.001). Also, the SFCT of the unaffected fellow eyes was lower than that of the healthy control eyes (P=0.033). The superficial blood flow area and vascular density of choriocapillary in the macular area were smaller and lower in the IMH eyes (2.84±0.35 mm2, 20.74%±8.26%) than the unaffected fellow eyes (3.19±0.23 mm2, 35.18%±5.20%) and healthy control eyes (3.26±0.24 mm2, 35.20%±6.49%) (P<0.001); however, no difference was observed between the unaffected fellow eyes and healthy control eyes.
The SFCT in IMH eyes was lower than that of unaffected fellow eyes and matched control eyes. In addition, the choriocapillary blood flow area and vascular density were smaller and lower than those of the unaffected fellow eyes and normal controls. Our findings suggested that atrophy of choriocapillary might play an important role in the formation of IMH.
应用光学相干断层扫描（OCT）和光学相干断层扫描血管造影（OCTA）观察特发性黄斑裂孔（IMH）患眼、对侧眼及正常对照眼的中心凹下脉络膜厚度（SFCT）和脉络膜毛细血管循环的变化，探讨 SFCT 和脉络膜毛细血管循环在 IMH 发病机制中的作用。
该病例系列研究纳入了 30 例单侧 IMH 患者和 30 名年龄、性别匹配的对照者。30 例单侧 IMH 患者的 30 只眼、对侧眼及 30 名年龄、性别匹配的健康对照者纳入研究。应用频域增强深度成像 OCT（EDI SD-OCT）测量 SFCT，应用 OCTA 测量脉络膜毛细血管循环的血管密度和血流面积。
IMH 眼的 SFCT（236.09±79.25 µm）低于对侧眼（249.71±86.10 µm）（P=0.040）和正常对照眼（283.29±64.16 µm）（P=0.001）。此外，对侧眼的 SFCT 也低于正常对照眼（P=0.033）。IMH 眼黄斑区脉络膜毛细血管浅层血流面积和血管密度（2.84±0.35 mm2，20.74%±8.26%）小于对侧眼（3.19±0.23 mm2，35.18%±5.20%）和正常对照眼（3.26±0.24 mm2，35.20%±6.49%）（P<0.001）；然而，对侧眼与正常对照眼之间无差异。
IMH 眼的 SFCT 低于对侧眼和匹配的正常对照眼。此外，脉络膜毛细血管血流面积和血管密度小于对侧眼和正常对照眼。这些发现提示脉络膜毛细血管萎缩可能在 IMH 的形成中起重要作用。
