The Talent Culturing Plan for Leading Disciplines of Shandong Province, Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong, 273155, People's Republic of China.
Anal Bioanal Chem. 2021 Sep;413(21):5309-5320. doi: 10.1007/s00216-021-03504-3. Epub 2021 Jul 15.
Although many satisfactory studies have been developed for biomolecule detection, the complexity of biofluids still poses a major challenge to improve the performance of nanomaterials as electrochemical sensors. Herein, unprecedented polyoxometalate-based metal-organic frameworks (POMOFs) with 8-fold meso-helical feature, [Ag(trz)][PMoO] (PAZ), were synthesized and explored as electrochemical sensors to detect dopamine (DA). To improve the conductivity of PAZ and the binding ability with single-walled carbon nanotubes (SWCNTs), the nanocomposite of carboxyl functionalized SWCNTs (SWCNTs-COOH) with nano-PAZ (NPAZ), NPAZ@SWCNTs-COOH, was fabricated, and transmission electron microscopy (TEM) shows that NPAZ can interact stably and uniformly with SWCNTs-COOH, owing to more defect sites on the surface of SWCNTs-COOH. The electrochemical result of NPAZ@SWCNTs-COOH/GCE towards detecting DA shows that the linear range was from 0.05 to 100 μM with a detection limit (LOD) of 8.6 nM (S/N = 3). A new electrochemical biosensing platform by combining 8-fold helical POMOFs with SWCNTs-COOH was developed for enhancing detection of dopamine for the first time, exhibiting the lowest detection limit to date.
尽管已经有许多令人满意的研究用于生物分子检测，但生物流体的复杂性仍然对提高纳米材料作为电化学传感器的性能构成了重大挑战。在此，首次合成了具有 8 倍介孔螺旋特征的基于多金属氧酸盐的金属有机骨架（POMOF）[Ag(trz)][PMoO]（PAZ），并将其探索为电化学传感器以检测多巴胺（DA）。为了提高 PAZ 的导电性和与单壁碳纳米管（SWCNTs）的结合能力，制备了羧基功能化的 SWCNTs（SWCNTs-COOH）与纳米 PAZ（NPAZ）的纳米复合材料 NPAZ@SWCNTs-COOH，透射电子显微镜（TEM）表明 NPAZ 可以与 SWCNTs-COOH 稳定且均匀地相互作用，这是由于 SWCNTs-COOH 表面有更多的缺陷位。NPAZ@SWCNTs-COOH/GCE 对检测 DA 的电化学结果表明，线性范围为 0.05 至 100 μM，检测限（LOD）为 8.6 nM（S/N = 3）。首次开发了一种将 8 倍螺旋 POMOF 与 SWCNTs-COOH 结合的新型电化学生物传感平台，以提高多巴胺的检测能力，其检测限是迄今为止最低的。
