Beijing Obstetrics and Gynaecology Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2021 Jul;49(7):3000605211028028. doi: 10.1177/03000605211028028.
To assess the prevalence and survival rate of newborns with a delayed diagnosis of critical congenital heart defects (CCHD) in Beijing.
This retrospective study analysed data from births between 2010 and 2017 from the Birth Defects Monitoring Network in Beijing. Newborns with CCHD were analysed according to seven categories. Statistical analyses were used to calculate the mortality rate within the first week (days 0-6) after live birth. Multivariate logistic regression analysis of survival was performed to analyse the potential risk factors for newborn mortality.
A total of 1 773 935 perinatal newborns were screened in Beijing and 1851 newborns were diagnosed with CCHD, showing a prevalence of 10.43 per 10 000. Among the total 1851 CCHD patients, the majority (1692 of 1851; 91.41%) were identified through prenatal diagnosis, 104 of 1851 (5.62%) were diagnosed before obstetric discharge/transfer and 55 of 1851 (2.97%) were identified through delayed diagnosis. The prevalence of CCHD in newborns was 1.96 per 10 000 births. Multivariate logistic regression analysis of survival demonstrated that gestational age at delivery was the only risk factor for death within the first week after birth.
Within the first week after birth, gestational age was the only risk factor for death in newborns with CCHD.
评估北京地区迟发型严重先天性心脏病（CCHD）新生儿的患病率和存活率。
本回顾性研究分析了 2010 年至 2017 年期间北京出生缺陷监测网络的数据。根据七个类别分析 CCHD 新生儿。统计分析用于计算活产后第一周（0-6 天）内的死亡率。采用多变量逻辑回归分析对新生儿死亡的潜在危险因素进行分析。
在北京，共筛查了 1773935 例围产儿新生儿，1851 例新生儿被诊断为 CCHD，患病率为 10.43/10000。在 1851 例 CCHD 患者中，大多数（1692/1851；91.41%）通过产前诊断发现，104/1851（5.62%）在产科出院/转院前诊断，55/1851（2.97%）通过迟发型诊断发现。新生儿 CCHD 的患病率为 1.96/10000 出生。对存活率的多变量逻辑回归分析表明，分娩时的胎龄是出生后第一周内死亡的唯一危险因素。
在出生后第一周内，胎龄是 CCHD 新生儿死亡的唯一危险因素。
