Department of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Int J Radiat Biol. 2021;97(10):1333-1340. doi: 10.1080/09553002.2021.1956007. Epub 2021 Jul 28.
Radiation-induced heart disease (RIHD) is one of the most serious complications of radiotherapy. The purpose of this paper is to review recent researches about cardiac toxicity of radiotherapy in clinical characteristics, mechanisms, diagnosis, and prevention.
Powered by the rapid development of medicine, the overall survival (OS) of cancer has been improved significantly. Surgery, chemotherapy, and radiotherapy (RT) are three critical ways in the comprehensive treatments of cancer. There is a consensus that early diagnosis and interventions for the prevention of RIHD are crucial. This review concludes recent clinical and experimental studies on RIHD. RIHD, a heterogeneous and serious disease, is a spectrum of heart disease including myocardial disease, pericarditis, coronary artery disease, valvular heart disease, and conduction system dysfunction. Mean heart dose, biomarkers, and detecting techniques are important components in detecting heart injury. Improvements in radiotherapy regimens remain the primary goal of prevention. Further investigation is needed beyond the observation period of most of these studies.
放射性心脏病（RIHD）是放射治疗最严重的并发症之一。本文旨在回顾放射治疗中心脏毒性的临床特征、机制、诊断和预防的最新研究。
得益于医学的快速发展，癌症的总体生存率（OS）得到了显著提高。手术、化疗和放疗（RT）是癌症综合治疗的三种重要方法。人们普遍认为，早期诊断和干预预防 RIHD 至关重要。本综述总结了最近关于 RIHD 的临床和实验研究。RIHD 是一种异质性和严重的疾病，是包括心肌疾病、心包炎、冠状动脉疾病、瓣膜性心脏病和传导系统功能障碍在内的一系列心脏病。平均心脏剂量、生物标志物和检测技术是检测心脏损伤的重要组成部分。改善放疗方案仍然是预防的主要目标。除了这些研究的大部分观察期之外，还需要进一步的研究。
