Eber Jordan, Blondet Cyrille, Le Fevre Clara, Chambrelant Isabelle, Hubele Fabrice, Morel Olivier, Antoni Delphine, Noel Georges
Institut de Cancérologie Strasbourg Europe (ICANS), Department of Radiation Oncology, Strasbourg, France.
Institut de Cancérologie Strasbourg Europe (ICANS), Department of Nuclear Medicine, Strasbourg, France.
Front Oncol. 2023 Oct 9;13:1240889. doi: 10.3389/fonc.2023.1240889. eCollection 2023.
Radiotherapy has significantly improved cancer survival rates, but it also comes with certain unavoidable complications. Breast and thoracic irradiation, for instance, can unintentionally expose the heart to radiation, leading to damage at the cellular level within the myocardial structures. Detecting and monitoring radiation-induced heart disease early on is crucial, and several radionuclide imaging techniques have shown promise in this regard.
In this 10-year review, we aimed to identify nuclear medicine imaging modalities that can effectively detect early cardiotoxicity following radiation therapy. Through a systematic search on PubMed, we selected nineteen relevant studies based on predefined criteria.
The data suggest that incidental irradiation of the heart during breast or thoracic radiotherapy can cause early metabolic and perfusion changes. Nuclear imaging plays a prominent role in detecting these subclinical effects, which could potentially serve as predictors of late cardiac complications.
However, further studies with larger populations, longer follow-up periods, and specific heart dosimetric data are needed to better understand the relationship between early detection of cardiac abnormalities and radiation-induced heart disease.
放射治疗显著提高了癌症存活率，但也伴随着某些不可避免的并发症。例如，乳腺和胸部放疗可能会意外地使心脏受到辐射，导致心肌结构内细胞水平的损伤。早期检测和监测放射性心脏病至关重要，几种放射性核素成像技术在这方面已显示出前景。
在这项为期10年的综述中，我们旨在确定能够有效检测放疗后早期心脏毒性的核医学成像模式。通过在PubMed上进行系统检索，我们根据预定义标准选择了19项相关研究。
数据表明，乳腺或胸部放疗期间心脏的意外照射可导致早期代谢和灌注变化。核成像在检测这些亚临床效应方面发挥着重要作用，这些效应可能是晚期心脏并发症的预测指标。
然而，需要进行更大规模人群、更长随访期以及特定心脏剂量学数据的进一步研究，以更好地理解心脏异常的早期检测与放射性心脏病之间的关系。
