Danish Centre for Sleep Medicine, Copenhagen University Hospital- Rigshospitalet-Glostrup, Copenhagen, Denmark.
Copenhagen University, Panum Institute, Denmark; Molecular Sleep Laboratory, Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark.
Sleep Med. 2021 Sep;85:1-7. doi: 10.1016/j.sleep.2021.06.033. Epub 2021 Jun 29.
Differentiating between the central hypersomnias presents a challenge to the diagnosis of patients with hypersomnolence. Actitigraphy may support efforts to distinguish them. We aimed to evaluate: 1) the ability of actigraphy to quantify sleep continuity measures in comparison with polysomnography in patients with hypersomnolence; 2) whether actigraphy can distinguish patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid from patients with narcolepsy type 1 and from sleep-healthy controls; and 3) the distinct activity profiles and circadian rhythms of patients with narcolepsy type 1, patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid, and sleep-healthy controls.
Polysomnography, multiple sleep latency tests and actigraphy were conducted in 14 patients with narcolepsy type 1, 29 patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid and 15 sleep-healthy controls.
Actigraphy quantified several sleep continuity measures consistently with polysomnography in all the patients. Actigraphy distinguished patients with hypersomnolence with normal hypocretin-1 in cerebrospinal fluid from patients with narcolepsy type 1 and sleep-healthy controls. Patients with narcolepsy type 1 had poor sleep quality and altered circadian rest-activity rhythm compared with controls.
Actigraphy is an adequate tool for establishing the amount of night sleep and supports the differential diagnosis of patients with hypersomnolence.
区分中枢性嗜睡症具有挑战性，这对嗜睡症患者的诊断提出了要求。活动记录仪可能有助于区分它们。我们旨在评估：1）与多导睡眠图相比，活动记录仪在评估嗜睡症患者的睡眠连续性测量方面的能力；2）活动记录仪是否可以区分脑脊液中正常食欲素-1的嗜睡症患者与 1 型发作性睡病患者和睡眠健康对照者；3）1 型发作性睡病患者、脑脊液中正常食欲素-1的嗜睡症患者和睡眠健康对照者的不同活动模式和昼夜节律。
对 14 例 1 型发作性睡病患者、29 例脑脊液中正常食欲素-1的嗜睡症患者和 15 例睡眠健康对照者进行了多导睡眠图、多次睡眠潜伏期试验和活动记录仪检查。
在所有患者中，活动记录仪都能一致地定量评估几个睡眠连续性测量指标，与多导睡眠图一致。活动记录仪能将脑脊液中正常食欲素-1的嗜睡症患者与 1 型发作性睡病患者和睡眠健康对照者区分开来。与对照组相比，1 型发作性睡病患者的睡眠质量较差，昼夜休息-活动节律改变。
活动记录仪是评估夜间睡眠时间的有效工具，并支持嗜睡症患者的鉴别诊断。
