1型发作性睡病患者的下丘脑分泌素-1水平与睡眠片段化相关。
Hypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1.
作者信息
Alakuijala Anniina, Sarkanen Tomi, Partinen Markku
机构信息
Department of Clinical Neurophysiology, HUS Medical Imaging Center, Helsinki University Central Hospital, Finland.
Department of Neurological Sciences, University of Helsinki, Helsinki, Finland.
出版信息
Sleep. 2016 May 1;39(5):1047-50. doi: 10.5665/sleep.5750.
STUDY OBJECTIVES
We aimed to analyze nocturnal sleep characteristics of patients with narcolepsy type 1 (narcolepsy with cataplexy) measured by actigraphy in respect to cerebrospinal fluid hypocretin-1 levels of the same patients.
METHODS
Actigraphy recording of 1-2 w and hypocretin-1 concentration analysis were done to thirty-six unmedicated patients, aged 7 to 63 y, 50% female. Twenty-six of them had hypocretin-1 levels under 30 pg/mL and the rest had levels of 31-79 pg/mL.
RESULTS
According to actigraphy, patients with very low hypocretin levels had statistically significantly longer sleep latency (P = 0.033) and more fragmented sleep, indicated by both the number of immobile phases of 1 min (P = 0.020) and movement + fragmentation index (P = 0.049). There were no statistically significant differences in the actual sleep time or circadian rhythm parameters measured by actigraphy.
CONCLUSIONS
Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep.
研究目的
我们旨在通过活动记录仪分析1型发作性睡病（伴猝倒的发作性睡病）患者的夜间睡眠特征，并将其与这些患者的脑脊液下丘脑分泌素-1水平进行对比。
方法
对36例未接受药物治疗的患者进行了为期1 - 2周的活动记录仪记录及下丘脑分泌素-1浓度分析，这些患者年龄在7至63岁之间，50%为女性。其中26例患者的下丘脑分泌素-1水平低于30 pg/mL，其余患者的水平为31 - 79 pg/mL。
结果
根据活动记录仪记录结果，下丘脑分泌素水平极低的患者，其睡眠潜伏期在统计学上显著更长（P = 0.033），睡眠更碎片化，这通过1分钟静止期的数量（P = 0.020）和运动 + 碎片化指数（P = 0.049）得以体现。通过活动记录仪测量的实际睡眠时间或昼夜节律参数没有统计学上的显著差异。
结论
活动记录仪为1型发作性睡病患者的睡眠稳定性提供了额外信息。极低的下丘脑分泌素水平与更多的清醒状态侵入睡眠有关。
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