A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia; Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Handb Clin Neurol. 2021;182:333-354. doi: 10.1016/B978-0-12-819973-2.00023-X.
For the majority of hypertensive patients, the etiology of their disease is unknown. The hypothalamus is a central structure of the brain which provides an adaptive, integrative, autonomic, and neuroendocrine response to any fluctuations in physiological conditions of the external or internal environment. Hypothalamic insufficiency leads to severe metabolic and functional disorders, including persistent increase in blood pressure. Here, we discuss alterations in the neurochemical organization of the paraventricular and suprachiasmatic nucleus in the hypothalamus of patients who suffered from essential hypertension and died suddenly due to acute coronary failure. The changes observed are hypothesized to contribute to the pathogenesis of disease.
对于大多数高血压患者来说，他们的病因尚不清楚。下丘脑是大脑的一个中枢结构，它对外部或内部环境的任何生理条件的波动提供自适应、综合、自主和神经内分泌反应。下丘脑功能不全导致严重的代谢和功能障碍，包括持续性血压升高。在这里，我们讨论了因急性冠状动脉衰竭突然死亡的原发性高血压患者下丘脑室旁核和视交叉上核的神经化学组织改变。这些观察到的变化被假设有助于疾病的发病机制。
