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[新型冠状病毒肺炎中的肾损伤]

[Kidney damage in COVID-19].

作者信息

Burtey Stéphane, Sallée Marion

机构信息

Aix Marseille Univ, Inserm, INRAE, C2VN, 13005 Marseille, France; Aix-Marseille Univ, Centre de néphrologie et transplantation rénale, Hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France.

Aix Marseille Univ, Inserm, INRAE, C2VN, 13005 Marseille, France; Aix-Marseille Univ, Centre de néphrologie et transplantation rénale, Hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France.

出版信息

Nephrol Ther. 2021 Aug;17(4):203-207. doi: 10.1016/j.nephro.2021.06.002. Epub 2021 Jun 23.

Abstract

COVID-19 is a disease caused by the RNA virus SARS-CoV-2. It is characterised by an attack mainly affecting the respiratory system. There is renal involvement which is characterised by three main types of damage, acute tubular necrosis occurring in the most severe cases, proximal tubulopathy which is a prognostic marker of the disease and segmental and focal hyalinosis occurring in a genetically predisposed terrain. The pathophysiology of SARS-CoV-2 renal involvement is not yet defined. The direct role of the virus is debated, whereas the cytokine storm and the hypoxic and thrombotic complications seem more important. The long-term outcome of the renal damage appears to be quite good. Long-term follow-up will allow us to say whether the renal damage is part of the long COVID.

摘要

新冠病毒病(COVID-19)是一种由RNA病毒严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的疾病。其特征是主要侵袭呼吸系统。存在肾脏受累情况,其特征为三种主要类型的损伤,最严重的病例中会出现急性肾小管坏死,近端肾小管病是该疾病的一个预后标志物,而节段性和局灶性玻璃样变则发生在具有遗传易感性的人群中。SARS-CoV-2肾脏受累的病理生理学尚未明确。病毒的直接作用存在争议,而细胞因子风暴以及缺氧和血栓形成并发症似乎更为重要。肾脏损伤的长期预后似乎相当良好。长期随访将使我们能够确定肾脏损伤是否是新冠后状况的一部分。

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