Pediatrics, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Pediatric Endocrinology and Diabetology Unit, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal.
BMJ Case Rep. 2021 Jul 15;14(7):e242278. doi: 10.1136/bcr-2021-242278.
The most frequent type of thyroid malignancy in children is papillary thyroid carcinoma (PTC), which usually presents as a thyroid nodule, but may also present as a diffuse infiltration with microcalcifications. Herein, we report the case of an uncommon presentation of a PTC in a 7-year-old boy. The child was referred for a goiter with cervical lymphadenopathies. Ultrasonography showed a hypervascularised goiter without microcalcifications but with numerous bilateral cervical nodular formations. A lymph node biopsy revealed metastatic thyroid cancer, hence a total thyroidectomy and complete neck dissection were performed. Histopathology confirmed a PTC. Ablative I, 30 mCi was performed 4 months postsurgery. At the end of this treatment, a metastatic lung nodule was identified. Since then, another three ablative I treatments have been administered. Thyroid cancers presenting as a diffuse infiltration without microcalcifications are rare. In the presence of lymphadenopathies, thyroid cancer needs to be suspected, even without microcalcifications.
儿童最常见的甲状腺恶性肿瘤是甲状腺乳头状癌(PTC),通常表现为甲状腺结节,但也可能表现为弥漫性浸润伴微钙化。本文报道了一例 7 岁男孩罕见的 PTC 表现。患儿因甲状腺肿伴颈部淋巴结病就诊。超声显示甲状腺肿呈多血管化,无微钙化,但有许多双侧颈部结节形成。淋巴结活检显示转移性甲状腺癌,因此行甲状腺全切除术和颈淋巴结清扫术。组织病理学证实为 PTC。术后 4 个月行 I 治疗 30mCi。在治疗结束时,发现一个转移性肺结节。此后,又进行了三次 I 治疗。不伴微钙化的弥漫性浸润性甲状腺癌很少见。存在淋巴结病时,即使没有微钙化,也需要怀疑甲状腺癌。