Andersson S H, Cronholm T, Sjövall J
Department of Physiological Chemistry, Karolinska Instituet, Stockholm, Sweden.
Alcohol Alcohol Suppl. 1987;1:529-31.
The effects of ethanol, 0.3 g/kg body weight, on the concentrations of testosterone, androsterone, estradiol and estrone in unconjugated as well as conjugated forms in plasma of men were analyzed by gas chromatography-mass spectrometry using labelled internal standards. The concentrations of unconjugated steroids remained unchanged while the concentrations of estradiol conjugates increased markedly in all subjects in parallel with the alcohol concentration in blood. The results indicate that the reduction of the 17-oxo group of estrogen conjugates is influenced by the altered redox state in the liver during ethanol oxidation. The increased formation of estradiol conjugates combined with their hydrolysis in target organs could be one of the mechanisms behind the feminizing effects of ethanol.
采用气相色谱-质谱联用仪并使用标记内标物，分析了体重0.3 g/kg乙醇对男性血浆中游离及结合形式的睾酮、雄酮、雌二醇和雌酮浓度的影响。所有受试者血浆中游离甾体类激素的浓度未发生变化，而雌二醇结合物的浓度随血液中酒精浓度的升高显著增加。结果表明，乙醇氧化过程中肝脏氧化还原状态的改变影响了雌激素结合物17-氧代基团的还原。雌二醇结合物生成增加并在靶器官中水解，可能是乙醇产生女性化作用的机制之一。
