Andersson S H, Cronholm T, Sjövall J
J Steroid Biochem. 1986 Jun;24(6):1193-8. doi: 10.1016/0022-4731(86)90382-1.
The concentrations in plasma of estradiol, estrone, testosterone and 4-androstene-3,17-dione and their monosulphates and glucuronides were determined after oral administration of 0.3 g ethanol per kg body weight to four men. The levels of the unconjugated steroids did not change in a consistent way. In contrast, the concentrations of estradiol monosulphate and estradiol glucuronide increased markedly. The increase paralleled the blood alcohol concentrations and control levels were reached 3 h after the ethanol intake. A coupling of ethanol oxidation with reduction of dehydroepiandrosterone sulphate has previously been established, and it is suggested that the ethanol-induced change of the hepatic redox level affects the interconversion of conjugated forms of estradiol and estrone resulting in elevated levels of conjugated estradiol. This could have a feminizing effect and affect the feed-back regulation of gonadal hormone production.
对四名男性每千克体重口服0.3克乙醇后，测定了血浆中雌二醇、雌酮、睾酮、4-雄烯-3,17-二酮及其单硫酸盐和葡萄糖醛酸苷的浓度。未结合类固醇的水平没有以一致的方式变化。相比之下，雌二醇单硫酸盐和雌二醇葡萄糖醛酸苷的浓度显著增加。这种增加与血醇浓度平行，乙醇摄入后3小时达到对照水平。先前已经证实乙醇氧化与硫酸脱氢表雄酮还原之间存在偶联，并且有人提出乙醇诱导的肝脏氧化还原水平变化会影响雌二醇和雌酮结合形式的相互转化，从而导致结合雌二醇水平升高。这可能会产生女性化作用，并影响性腺激素产生的反馈调节。
