Endocrinology Unit, Paediatric University Hospital Department, "Bambino Gesù" Children's Hospital, IRCCS, Rome, Italy.
Research Area for Multifactorial Diseases and Complex Phenotypes, "Bambino Gesù" Children's Hospital, IRCCS, Rome, Italy.
Bone. 2021 Dec;153:116114. doi: 10.1016/j.bone.2021.116114. Epub 2021 Jul 14.
Fetal growth patterns and birth weight (BW) have been associated with bone mineral density (BMD) and content (BMC) throughout infancy and childhood up to early adulthood. We hypothesized that in small for gestational age (SGA) children, compensatory infant catch-up growth to normal height centiles counteracts the adverse consequences of low BW on bone accrual.
To evaluate BMD and BMC of SGA children born at term who experienced a normal catch-up growth as compared to children born appropriate for gestational age (AGA).
We recruited 53 SGA (26 females) and 60 AGA children (27 females), aged 6 to 18 years, matched for sex and body mass index (BMI). Fat mass (FM); Free fat mass (FFM); Lumbar spine and Total body less head (TBLH) BMD; BMC and BMD standard deviation scores corrected for body size (BMAD, BMAD z-score and TBLH BMD/Height) and TBLH BMC for FFM (TBLHBMC/FFM) were derived from Dual Energy X-ray absorptiometry (DXA) scans.
SGA and AGA children did not differ in any auxological, body composition and bone parameters appropriately adjusted for height and FFM. BMI, FM and, remarkably, FFM were significantly correlated with bone mass parameters in both groups while no correlation was found between FM and FFM with the BW SDS in the univariate analysis.
Our preliminary data demonstrate that SGA children born at term who recover from their growth deficiency through catch-up growth achieve bone mass and body composition not different from children born AGA.
胎儿生长模式和出生体重（BW）与婴儿期和儿童期直至成年早期的骨密度（BMD）和骨量（BMC）有关。我们假设，在小于胎龄儿（SGA）中，追赶生长至正常身高百分位以补偿 BW 对骨量积累的不良影响。
评估足月出生且经历正常追赶生长的 SGA 儿童与适于胎龄（AGA）出生的儿童的 BMD 和 BMC。
我们招募了 53 名 SGA（26 名女性）和 60 名 AGA 儿童（27 名女性），年龄 6 至 18 岁，性别和体重指数（BMI）匹配。从双能 X 射线吸收法（DXA）扫描中得出脂肪量（FM）；去脂体重（FFM）；腰椎和全身除头部（TBLH）BMD；根据身体大小校正的 BMC 标准偏差分数（BMAD、BMAD z 评分和 TBLH BMC/身高）和 FFM 的 TBLH BMC（TBLHBMC/FFM）。
SGA 和 AGA 儿童在任何身高和 FFM 适当调整的生长参数、身体成分和骨骼参数方面均无差异。BMI、FM，特别是 FFM 在两组中均与骨量参数显著相关，而在单变量分析中，FM 和 FFM 与 BW SDS 之间未发现相关性。
我们的初步数据表明，足月出生且通过追赶生长恢复生长缺陷的 SGA 儿童，其骨量和身体成分与 AGA 出生的儿童无差异。
