大鼠中脑导水管周围灰质对刺激产生的镇痛作用耐受性发展中的部位特异性
Site specificity in the development of tolerance to stimulation-produced analgesia from the periaqueductal gray matter of the rat.
作者信息
Morgan M M, Liebeskind J C
机构信息
Department of Psychology, University of California, Los Angeles 90024-1563.
出版信息
Brain Res. 1987 Nov 10;425(2):356-9. doi: 10.1016/0006-8993(87)90519-1.
Pentobarbital-anesthetized rats were subjected to 21 min of continuous electrical stimulation of the caudal periaqueductal gray matter (PAG) at the current threshold for analgesia. Stimulation at ventral PAG sites supported analgesia for only 1 or 2 min in most animals. Stimulation at more dorsal PAG sites supported analgesia for the entire 21 min of stimulation. This demonstration of acute tolerance with continuous ventral, but not more dorsal, PAG stimulation corresponds well with previous evidence suggesting opioid mediation of analgesia from this brain region.
将戊巴比妥麻醉的大鼠置于镇痛电流阈值下，对其尾侧导水管周围灰质（PAG）进行21分钟的连续电刺激。在大多数动物中，刺激腹侧PAG部位仅能维持1或2分钟的镇痛效果。而刺激PAG更靠背侧的部位，则能在整个21分钟的刺激过程中维持镇痛效果。这种连续刺激腹侧而非更靠背侧的PAG部位会产生急性耐受性的现象，与之前表明该脑区阿片类物质介导镇痛的证据非常吻合。
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