Ranasinghe A W, Johnson N W, Scragg M A
Department of Oral Medicine, Dental School, University of Peradeniya, Sri Lanka.
Cell Tissue Kinet. 1987 Jul;20(4):403-12. doi: 10.1111/j.1365-2184.1987.tb01325.x.
Iron deficiency anaemia was induced in hamsters by feeding a low iron diet coupled with weekly bleeding. To assess cell proliferation, the stathmokinetic agent vinblastine sulphate was administered and cell birth rates were calculated from cumulative mitotic indices. The rate was significantly reduced in epithelium from iron-deficient animals. The uptake of tritiated thymidine [( 3H]TdR) was also significantly reduced in these animals. Results of both stathmokinetic and labelling experiments indicate that cell production in the cheek pouch epithelium of iron-deficient animals is impaired.
通过给仓鼠喂食低铁饮食并每周放血来诱导缺铁性贫血。为了评估细胞增殖，给予有丝分裂抑制剂硫酸长春碱，并根据累积有丝分裂指数计算细胞出生率。缺铁动物上皮细胞的细胞出生率显著降低。这些动物中氚标记胸腺嘧啶核苷[³H]TdR的摄取也显著减少。有丝分裂抑制实验和标记实验的结果均表明，缺铁动物颊囊上皮细胞的生成受到损害。
