Mazzoni A, Fiacchini M, Cevenini R, Gatti M, Nanetti A
Institute of Microbiology, Policlinico S. Orsola, Bologna, Italy.
Chemioterapia. 1987 Oct;6(5):374-6.
Two groups of immunocompromised patients were studied with the aim of pointing out the possibilities of antifungal prophylaxis in this type of patient. All patients received oral treatment with nystatin, but only the patients of one group were also in strict reverse isolation. It has been confirmed that chemoprophylactic treatments may control opportunistic endogenous mycoses effectually. On the contrary, only reverse isolation seems to be effective against airborne exogenous fungal infections. Because of the difficulty and high cost of this practice, different modalities for a really generalizable antifungal prophylaxis are required. At present only the detection of new systemic antifungal drugs, which are not toxic and are easy to use, seems hopeful.
对两组免疫功能低下的患者进行了研究，目的是指出这类患者进行抗真菌预防的可能性。所有患者均接受制霉菌素口服治疗，但只有一组患者同时进行严格的反向隔离。已经证实，化学预防治疗可以有效地控制机会性内源性真菌病。相反，似乎只有反向隔离对空气传播的外源性真菌感染有效。由于这种做法的难度和高成本，需要不同的方式来进行真正可推广的抗真菌预防。目前，只有检测无毒且易于使用的新型全身性抗真菌药物似乎有希望。
