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Could patients benefit from whole-brain radiotherapy with unilateral hippocampus sparing?

作者信息

Sapienza Lucas Gomes, Ludwig Michelle S, Mandel Jacob J, Nguyen Dung H, Echeverria Alfredo Enrique

机构信息

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.

Department of Neurology, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.

出版信息

Rep Pract Oncol Radiother. 2021 Jun 9;26(3):454-456. doi: 10.5603/RPOR.a2021.0059. eCollection 2021.

DOI:10.5603/RPOR.a2021.0059
PMID:34277100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8281911/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c4/8281911/c392f0f43d16/rpor-26-3-454f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c4/8281911/c392f0f43d16/rpor-26-3-454f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58c4/8281911/c392f0f43d16/rpor-26-3-454f1.jpg

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本文引用的文献

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Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors.预测长期神经认知结果的海马放射治疗剂量限制：来自年轻脑瘤患者前瞻性试验的成熟数据。
Neuro Oncol. 2020 Nov 26;22(11):1677-1685. doi: 10.1093/neuonc/noaa076.
2
Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.全脑放疗联合美金刚治疗脑转移瘤患者时对海马的回避：NRG 肿瘤学 CC001 期临床试验。
J Clin Oncol. 2020 Apr 1;38(10):1019-1029. doi: 10.1200/JCO.19.02767. Epub 2020 Feb 14.
3
Hippocampal dose during Linac-based stereotactic radiotherapy for brain metastases: An observational study.
基于直线加速器的立体定向放疗治疗脑转移瘤的海马剂量：一项观察性研究。
Phys Med. 2018 May;49:135-138. doi: 10.1016/j.ejmp.2017.09.129. Epub 2017 Sep 23.
4
Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study.保留左侧海马的全脑放疗（WBRT）：一项计划研究。
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Dec;161(4):397-402. doi: 10.5507/bp.2017.031. Epub 2017 Jul 20.
5
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.体素内磁共振波谱测量 WBRT 后认知障碍和海马神经元缺失：前瞻性研究结果。
Radiother Oncol. 2017 Mar;122(3):373-379. doi: 10.1016/j.radonc.2016.12.013. Epub 2017 Jan 4.
6
Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for brain metastases: a dosimetric volumetric-modulated arc therapy study.全脑放疗联合海马回避和同步整合增敏治疗脑转移瘤：一项基于剂量学的容积调强弧形治疗研究。
Radiol Med. 2016 Jan;121(1):60-9. doi: 10.1007/s11547-015-0563-8. Epub 2015 Aug 1.
7
Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions.双侧内侧颞叶损伤在两个不同场合发生后出现严重失忆。
Neurol Sci. 2006 Jun;27(2):129-33. doi: 10.1007/s10072-006-0614-y.
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J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11-21. doi: 10.1136/jnnp.20.1.11.
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J Neurosci. 1986 Oct;6(10):2950-67. doi: 10.1523/JNEUROSCI.06-10-02950.1986.