Chen S J, Ko H S
Clinical Immunology Unit, University Hospital, London, Ontario, Canada.
Clin Exp Immunol. 1987 Nov;70(2):263-7.
Serum thymosin-alpha 1 levels as detected by radioimmunoassay (RIA) have been reported to be elevated in AIDS. We studied 143 individuals in two risk groups for AIDS (male homosexuals and haemophiliacs) for serum thymosin-alpha 1 and antibodies to HIV. RIA for thymosin-alpha 1 was performed in Dr A. Goldstein's laboratory at George Washington University, Washington DC. We found that similar proportions of seropositive and seronegative subjects within each risk group showed elevated thymosin-alpha 1 levels. Retesting after 6 months did not reveal significant increments over previous levels in seropositive subjects or in those developing HIV antibodies in the repeat samples. Thus, although elevated thymosin-alpha 1 levels might be a possible serum marker for AIDS, their association with HIV infection was not demonstrated. In addition, the male homosexuals we studied showed significantly lower thymosin-alpha 1 levels than haemophiliacs but this difference remains to be explained.
据报道，通过放射免疫分析法（RIA）检测，艾滋病患者血清胸腺素α1水平升高。我们对两组艾滋病高危人群（男性同性恋者和血友病患者）的143名个体进行了血清胸腺素α1和HIV抗体研究。胸腺素α1的放射免疫分析在华盛顿特区乔治·华盛顿大学的A. 戈尔茨坦博士实验室进行。我们发现，每个风险组中血清阳性和血清阴性受试者中胸腺素α1水平升高的比例相似。6个月后重新检测未发现血清阳性受试者或重复样本中出现HIV抗体的受试者的胸腺素α1水平较之前有显著升高。因此，虽然胸腺素α1水平升高可能是艾滋病的一种潜在血清标志物，但未证实其与HIV感染有关。此外，我们研究的男性同性恋者的胸腺素α1水平显著低于血友病患者，但这种差异仍有待解释。
