State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China.
Chem Commun (Camb). 2021 Aug 5;57(63):7826-7829. doi: 10.1039/d1cc02670d.
A transformable upconversion MOF comprising a UCNP core and an azobenzene-based MOF shell is designed for NIR light-modulated chemotherapy. The dual Förster resonance energy transfers (FRETs) involved in this delivery system trigger the transformation of the MOF for drug release and prodrug activation, thus significantly inhibiting the tumor growth and metastasis.
设计了一种可变形上转换 MOF，包含 UCNP 核和基于偶氮苯的 MOF 壳，用于 NIR 光调控化疗。该递药系统中涉及的双重Förster 共振能量转移（FRET）触发 MOF 的转变以实现药物释放和前药激活，从而显著抑制肿瘤生长和转移。
