通过超小锆金属有机框架纳米颗粒的双峰药物递送增强抗癌细胞毒性。
Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles.
作者信息
Abánades Lázaro Isabel, Abánades Lázaro Sandra, Forgan Ross S
机构信息
WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
出版信息
Chem Commun (Camb). 2018 Mar 13;54(22):2792-2795. doi: 10.1039/c7cc09739e.
PMID:29485148
Abstract
Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.
摘要
从锆金属有机框架材料（Zr MOFs）向癌细胞双输送二氯乙酸盐和5-氟尿嘧啶被发现可增强体外细胞毒性。调节粒径，更重要的是调节表面化学性质，通过促进小窝介导的内吞作用和胞质货物递送进一步提高细胞毒性。
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