Abánades Lázaro Isabel, Abánades Lázaro Sandra, Forgan Ross S
WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.
Chem Commun (Camb). 2018 Mar 13;54(22):2792-2795. doi: 10.1039/c7cc09739e.
Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.
从锆金属有机框架材料（Zr MOFs）向癌细胞双输送二氯乙酸盐和5-氟尿嘧啶被发现可增强体外细胞毒性。调节粒径，更重要的是调节表面化学性质，通过促进小窝介导的内吞作用和胞质货物递送进一步提高细胞毒性。
