Department of Laboratory and Medical Research Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, Guangdong 528308, P.R. China.
Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, Guangdong 528308, P.R. China.
Int J Oncol. 2021 Aug;59(2). doi: 10.3892/ijo.2021.5242. Epub 2021 Jul 19.
Leukemia is a group of malignant diseases of clonal hematopoietic stem‑progenitor cells and its pathological mechanisms remain to be elucidated. Genetic and epigenetic abnormalities, as well as microenvironmental factors, including cytokines, serve critical roles in leukaemogenesis. Macrophage migration inhibitory factor (MIF) has been presented as one of the key regulators in tumorigenesis, angiogenesis and tumor metastasis. This article focuses on the functional role of MIF and its pathway in cancer, particularly in leukemia. MIF/CD74 interaction serves prominent roles in tumor cell survival, such as upregulating BCL‑2 and CD84 expression, and activating receptor‑type tyrosine phosphatase ζ. Furthermore, MIF upregulation forms a pro‑tumor microenvironment in response to hypoxia‑induced factors and promotes pro‑inflammatory cytokine production. Additionally, polymorphisms of the MIF promoter sequence are associated with leukemia development. MIF signal‑targeted early clinical trials show positive results. Overall, these efforts provide a promising means for intervention in leukemia.
白血病是一组克隆性造血干/祖细胞恶性疾病，其病理机制尚待阐明。遗传和表观遗传异常以及细胞因子等微环境因素在白血病发生中起着关键作用。巨噬细胞移动抑制因子（MIF）已被证明是肿瘤发生、血管生成和肿瘤转移的关键调节因子之一。本文重点介绍了 MIF 及其通路在癌症中的功能作用，特别是在白血病中的作用。MIF/CD74 相互作用在肿瘤细胞存活中起重要作用，如上调 BCL-2 和 CD84 的表达，并激活受体型酪氨酸磷酸酶 ζ。此外，MIF 的上调形成了对缺氧诱导因子的促肿瘤微环境，并促进促炎细胞因子的产生。此外，MIF 启动子序列的多态性与白血病的发生有关。MIF 信号靶向的早期临床试验显示出积极的结果。总的来说，这些努力为干预白血病提供了有希望的手段。
