Hino Christopher, Pham Bryan, Park Daniel, Yang Chieh, Nguyen Michael H K, Kaur Simmer, Reeves Mark E, Xu Yi, Nishino Kevin, Pu Lu, Kwon Sue Min, Zhong Jiang F, Zhang Ke K, Xie Linglin, Chong Esther G, Chen Chien-Shing, Nguyen Vinh, Castillo Dan Ran, Cao Huynh
Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Department of Internal Medicine, School of Medicine, University of California San Francisco-Fresno, Fresno, CA 93701, USA.
Biomedicines. 2022 Jun 14;10(6):1410. doi: 10.3390/biomedicines10061410.
The tumor microenvironment (TME) plays an essential role in the development, proliferation, and survival of leukemic blasts in acute myeloid leukemia (AML). Within the bone marrow and peripheral blood, various phenotypically and functionally altered cells in the TME provide critical signals to suppress the anti-tumor immune response, allowing tumor cells to evade elimination. Thus, unraveling the complex interplay between AML and its microenvironment may have important clinical implications and are essential to directing the development of novel targeted therapies. This review summarizes recent advancements in our understanding of the AML TME and its ramifications on current immunotherapeutic strategies. We further review the role of natural products in modulating the TME to enhance response to immunotherapy.
肿瘤微环境（TME）在急性髓系白血病（AML）中白血病母细胞的发育、增殖和存活中起着至关重要的作用。在骨髓和外周血中，TME中各种表型和功能发生改变的细胞提供关键信号以抑制抗肿瘤免疫反应，使肿瘤细胞能够逃避清除。因此，阐明AML与其微环境之间复杂的相互作用可能具有重要的临床意义，对于指导新型靶向治疗的开发至关重要。本综述总结了我们对AML TME的最新认识进展及其对当前免疫治疗策略的影响。我们还进一步综述了天然产物在调节TME以增强免疫治疗反应方面的作用。
