Hogg D, Gorin M B, Heinzmann C, Zollman S, Mohandas T, Klisak I, Sparkes R S, Breitman M, Tsui L C, Horwitz J
Mount Sinai Research Institute, Toronto, Ontario, Canada.
Curr Eye Res. 1987 Nov;6(11):1335-42. doi: 10.3109/02713688708997559.
We have identified and characterized two over-lapping bovine cDNA clones corresponding to the bovine crystallin beta Bp. The longer of the two clones, which contains the entire coding and 3' untranslated region as well as 54 nucleotides of the 5' untranslated sequence was used to identify and map an orthologous human gene, Hu beta B2, to chromosome 22, q11.2-q12.2. As one other human beta-crystallin, Hu beta A3/A1, has been mapped to chromosome 17, our results indicate that, unlike the tightly linked gamma-crystallins, the human beta-crystallins are not syntenic within the genome.
